Biological ActivityPotent and selective acid-sensing ion channel 1a (ASIC1a) blocker (IC50 = 0.9 nM). Displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and KV2.1/2.2/4.2/4.3 channels expressed in oocytes, at concentrations up to 100 nM. Displays potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents.
(Modifications: Disulfide bridge: 3-18, 10-23, 17-33)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.
Escoubas et al.
Protein Sci., 2003;12:1332
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
Escoubas et al.
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Mazzuca et al.
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.
Salinas et al.
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