Psalmotoxin 1

Name: Psalmotoxin 1
Brand: Tocris Bioscience
SKU: 5042
Price: 345 USD
Availability: InStock

Tocris Bioscience | Catalog # 5042

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Citations (6)

Product Documents

Potent and selective ASIC1a channel blocker

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective ASIC1a channel blocker

Alternative Names

PcTx1

View all Acid-sensing Ion Channel Blockers »

Product Description

Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker (IC₅₀ = 0.9 nM). Displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and K_V2.1/2.2/4.2/4.3 channels expressed in oocytes, at concentrations up to 100 nM. Displays potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents.

Product Specifications for Psalmotoxin 1

Molecular Weight

4689.41

Formula

C₂₀₀H₃₁₂N₆₂O₅₇S₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

316808-68-1

PubChem ID

90489000

InChI Key

LICLJUGDURFZIM-UHFFFAOYSA-N

SMILES

[H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Salinas The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J.Physiol. 2006 PMID: 16284080
Escoubas Isolation of a tarantula toxin specific for a class of proton-gated Na⁺ channels. J.Biol.Chem. 2000 PMID: 10829030
Escoubas Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci. 2003 PMID: 12824480
Mazzuca A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat.Neurosci. 2007 PMID: 17632507

Product Documents for Psalmotoxin 1

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Product Specific Notices for Psalmotoxin 1

For research use only

Citations for Psalmotoxin 1

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