Potent adenosine A2A
receptor full agonist (Ki
= 44.4 nM for rat brain striatal A2A
receptors). Exhibits subtype selectivity for A2A
receptors over A1
≥ 10 000 nM for rat A1
, human A2B
and human A3
receptors). Potentiates acetylcholine-induced contractions in ex vivo
rat ileum/jejunum segments.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists.
El-Tayeb et al.
ACS Med.Chem.Lett., 2012;2:890