Catalog Number: 3198
Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Biological Activity
Adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).
Technical Data
  • M.Wt:
    529.01
  • Formula:
    C24H25ClN6O4S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1092351-10-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
    Borrmann et al.
    J.Med.Chem., 2009;52:3994
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PSB 603 include:

5 Citations: Showing 1 - 5
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  1. Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices.
    Authors: Rao Et al.
    Front Bioeng Biotechnol 2015;3:185
  2. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death.
    Authors: Long Et al.
    J Pharmacol Exp Ther 2015;34:5152
  3. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
    Authors: Schneider Et al.
    Oncogene 2015;14:201
  4. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods 2015;12:661
  5. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
    Authors: Ham Et al.
    Proc Natl Acad Sci U S A 2010;335:607

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