PSB 603

Key Product Details

Product Description

PSB 603 is an adenosine A_2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (K_i values are 0.553, > 10000, > 10000 and > 10000 nM for A_2B, A₁, A_2A and A₃ receptors respectively). Downregulates the expression of osteocalcin and osteopontin during osteogenic differentiation of mesenchymal stem cells.

Product Specifications for PSB 603

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PSB 603

The following data is based on the product molecular weight 529.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.78 mL	18.90 mL	37.81 mL
2.5 mM	0.76 mL	3.78 mL	7.56 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 81 publications citing the usage of this product.

• Shih Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 24395775
• Borrmann 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 2009 PMID: 19569717

Product Documents for PSB 603