Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Biological ActivityAdenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Citations for PSB 603
The citations listed below are publications that use Tocris products. Selected citations for PSB 603 include:
6 Citations: Showing 1 - 6
Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.
Authors: Kang Et al.
Sci Adv 2016;2:e1600691
Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices.
Authors: Rao Et al.
Front Bioeng Biotechnol 2015;3:185
p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death.
Authors: Long Et al.
J Pharmacol Exp Ther 2015;34:5152
Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
Authors: Schneider Et al.
Application of BRET to monitor ligand binding to GPCRs.
Authors: Stoddart Et al.
Nat Methods 2015;12:661
Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
Authors: Ham Et al.
Proc Natl Acad Sci U S A 2010;335:607
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