PSEM 308 hydrochloride
Chemical Name: 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride
Biological ActivityPSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.
Recommended concentration for use in mice is 5 mg/kg or lower.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats.
Hirschberg et al.
Regulation of neuronal input transformations by tunable dendritic inhibition.
Lovett-Barron et al.
Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons.
Satoh et al.
Deconstruction of a neural circuit for hunger.
Atasoy et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PSEM 308 hydrochloride
There are currently no reviews for this product. Be the first to review PSEM 308 hydrochloride and earn rewards!
Have you used PSEM 308 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image