PSEM 308 hydrochloride

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PSEM 308 hydrochloride | PSEMs
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Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Chemical Name: 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride

Purity: ≥98%

Product Details

Biological Activity

PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.

Recommended concentration for use in mice is 5 mg/kg or lower.

Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in ethanol with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Product Datasheets

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