4 results for "PSEMs" in Products
PSEMs
PSAM and PSEM Mechanism of Action
Chemogenetic tools based on G protein-coupled receptors (GPCRs), like DREADDs and DREADD ligands, enable control of neuronal activity by engaging complex intracellular signaling pathways that result in changes in ion flux through endogenously expressed ion channels. PSAMs are chimeric ion channels that provide a more direct route to manipulation of ion flux and neuronal activity.
PSAMs were developed from initial research demonstrating that the ligand binding ...
Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
| Chemical Name: | 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride |
| Purity: | ≥98% |
Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
| Chemical Name: | 2-Propoxy-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline L-tartrate |
| Purity: | ≥98% |
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
| Chemical Name: | 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride |
| Purity: | ≥98% |
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
| Chemical Name: | N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate |
| Purity: | ≥98% |
