PSEM 89S

Key Product Details

Product Description

PSEM 89S is a PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ chimeric ion channel agonist (EC₅₀ values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAM^L141F,Y115F-5-HT₃ chimeric ion channels and inhibits activity of neurons expressing PSAM^L141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAM^L141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.

Plasmid vectors for the transfection of cells with PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ are available from Addgene.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Product Specifications for PSEM 89S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PSEM 89S

The following data is based on the product molecular weight 404.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Cerritelli Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 2016 PMID: 27077912
• Magnus Chemical and genetic engineering of selective ion channel-ligand interactions. Science 2011 PMID: 21885782

Product Documents for PSEM 89S