PSEM 89S

Catalog # Availability Size / Price Qty
6426/5
6426/25
Cat.No. 6426 - PSEM 89S | C16H22N2O3.CF3CO2H | CAS No. 1336913-03-1
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Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Chemical Name: N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate

Purity: ≥98%

Product Details
Reviews

Biological Activity

PSAM (pharmacologically selective actuator module) agonist. Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.

Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

Technical Data

M.Wt:
404.38
Formula:
C16H22N2O3.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1336913-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

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