PSENEN/PEN2 Antibody

Novus Biologicals | Catalog # NBP2-24611

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Bovine, Canine, Equine, Opossum

Predicted:

Monkey (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all PSENEN Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acid 1 to 50 of human Presenilin enhancer protein 2 was used as immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PSENEN/PEN2 Antibody

Western Blot: PSENEN/PEN2 Antibody [NBP2-24611]

Western Blot: PSENEN/PEN2 Antibody [NBP2-24611]

Western Blot: PSENEN/PEN2 Antibody [NBP2-24611] - Analysis of Presenilin enhancer protein 2 in human intestine lysate in the 1) absence and 2) presence of immunizing peptide and 3) mouse intestine lysate using NBP2-24611. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for PSENEN/PEN2 Antibody

Application
Recommended Usage

Western Blot

3-7 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PSENEN

Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.

Long Name

Presenilin Enhancer 2 Homolog

Alternate Names

PEN-2

Gene Symbol

PSENEN

UniProt

Q9NZ42

Additional PSENEN Products

Product Documents for PSENEN/PEN2 Antibody

Certificate of Analysis

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Product Specific Notices for PSENEN/PEN2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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