Psora 4

Tocris Bioscience | Catalog # 4367

Potent KV1.3 channel blocker
Tocris Bioscience

Key Product Details

Description

Potent KV1.3 channel blocker
View all Voltage-gated Potassium Channel Blockers »

Product Description

Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related KV1 channels (KV1, KV2, KV4 and KV7); exhibits activity at KV1.5 (IC50 = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC50 values are 25 and 60 nM respectively).

Product Specifications for Psora 4

Molecular Weight

334.37

Formula

C21H18O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

CAS Number

724709-68-6

PubChem ID

6603977

InChI Key

JJAWGNIQEOFURP-UHFFFAOYSA-N

SMILES

O=C2OC1=CC3=C(C=CO3)C(OCCCCC4=CC=CC=C4)=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.72 50
Ethanol 3.34 10

Preparing Stock Solutions for Psora 4

The following data is based on the product molecular weight 334.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.98 mL 29.91 mL 59.81 mL
2.5 mM 1.20 mL 5.98 mL 11.96 mL
5 mM 0.60 mL 2.99 mL 5.98 mL
25 mM 0.12 mL 0.60 mL 1.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Psora 4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Psora 4

For research use only

Customer Reviews for Psora 4 (1)

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  • Psora 4 was used on Kv3.1 channels to assess the blocking action exerted
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/27/2019
    Psora 4 was used on Kv3.1 channels in increasing concentrations to assess the blocking action exerted by Psora 4.Works ideally and gives publishable results.
    Psora 4 4367

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