Psora 4

Catalog # Availability Size / Price Qty
4367/10
4367/50
Psora 4 | CAS No. 724709-68-6 | Voltage-gated Potassium Channel Blockers
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Description: Potent KV1.3 channel blocker

Chemical Name: 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Potent KV1.3 channel blocker (EC50 = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related KV1 channels (KV1, KV2, KV4 and KV7); exhibits activity at KV1.5 (IC50 = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC50 values are 25 and 60 nM respectively).

Technical Data

M.Wt:
334.37
Formula:
C21H18O4
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
724709-68-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Psora 4 was used on Kv3.1 channels to assess the blocking action exerted
By Anonymous on 02/27/2019
Application: Species: Human

Psora 4 was used on Kv3.1 channels in increasing concentrations to assess the blocking action exerted by Psora 4.Works ideally and gives publishable results.


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