1.3 channel blocker (EC50
= 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818
(Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related KV
1 channels (KV
4 and KV
7); exhibits activity at KV
= 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC50
values are 25 and 60 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.
Vennekamp et al.
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
Schmitz et al.
Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism.
Li et al.
Am.J.Physiol.Cell Physiol., 2006;290:C345