Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Biological ActivityO-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol.
Dong and Hart
O-GlcNAcase uses substrate-assisted catalysis.
Macauley et al.
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.
Perreira et al.
Citations for (Z)-Pugnac
The citations listed below are publications that use Tocris products. Selected citations for (Z)-Pugnac include:
2 Citations: Showing 1 - 2
Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during in-Vitro Human Embryonic Cortical Neurogenesis.
Authors: Parween Et al.
Front Cell Neurosci 2018;11:415
O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.
Authors: Jo Et al.
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