-GlcNAcase) and β
-hexosaminidase inhibitor (Ki
values are 46 and 36 nM respectively) that increases O
-GlcNAc levels ~ 2-fold in HT29 cells. Z
-linked isomer is more potent than the E
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Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol.
Dong and Hart
O-GlcNAcase uses substrate-assisted catalysis.
Macauley et al.
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.
Perreira et al.