Catalog Number: 3384
Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Biological Activity
O-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol.
    Dong and Hart
    J.Biol.Chem., 1994;269:19321
  2. O-GlcNAcase uses substrate-assisted catalysis.
    Macauley et al.
    J.Biol.Chem., 2005;280:25313
  3. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.
    Perreira et al.
    Bioorg.Med.Chem., 2006;14:837
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