Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
Biological ActivityPuromycin dihydrochloride is a protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
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Citations for Puromycin dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:
8 Citations: Showing 1 - 8
SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance.
Authors: Yang Et al.
Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
Authors: Yu Et al.
PLoS One 2019;14:e0210608
AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
Authors: Ma Et al.
Am J Transl Res. 2017;9:507
WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.
Authors: Leung Et al.
Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.
Authors: Dasgupta Et al.
PLoS One 2015;10:e0145333
All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation.
Authors: Zhu Et al.
J Neurosci 2015;10:e0143255
Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Authors: Dasgupta Et al.
PLoS One 2014;9:e103604
Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
Authors: Dobrikov Et al.
Mol Cell Biol 2014;34:439
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