Puromycin dihydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:4089
Chemical Name:3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
Product Details
Citations (5)
Reviews
Biological Activity
Protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.
Technical Data
  • M.Wt:
    544.43
  • Formula:
    C22H29N7O5.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    58-58-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:

5 Citations: Showing 1 - 5
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  1. WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.
    Authors: Leung Et al.
    Development  2016;143:398
  2. Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.
    Authors: Dasgupta Et al.
    PLoS One  2015;10:e0145333
  3. All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation.
    Authors: Zhu Et al.
    J Neurosci  2015;10:e0143255
  4. Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
    Authors: Dasgupta Et al.
    PLoS One  2014;9:e103604
  5. Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
    Authors: Dobrikov Et al.
    Mol Cell Biol  2014;34:439

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