Protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro
and in vivo
systems. Also inhibits the transport of proteins into the mitochondria in vitro
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Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
Price and Verner
Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes.
Azzam and Algranati
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