Catalog Number: 4089
Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
Biological Activity
Protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.
Technical Data
  • M.Wt:
    544.43
  • Formula:
    C22H29N7O5.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    58-58-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
    Price and Verner
    Biochim.Biophys.Acta., 1993;1150:89
  2. Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes.
    Azzam and Algranati
    Proc.Nat.Acad.Sci., 1973;70:3866
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:

1 Citations: Showing 1 - 1

  1. All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation.
    Authors: Zhu Et al.
    J Neurosci 2015;10:e0143255

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