Puromycin dihydrochloride
Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
Purity: ≥98%
Biological Activity
Puromycin dihydrochloride is a protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
Price and Verner
Biochim.Biophys.Acta., 1993;1150:89
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Citations for Puromycin dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:
8 Citations: Showing 1 - 8
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SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance.
Authors: Yang Et al.
Autophagy 2019;:1
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Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
Authors: Yu Et al.
PLoS One 2019;14:e0210608
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AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
Authors: Ma Et al.
Am J Transl Res. 2017;9:507
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WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.
Authors: Leung Et al.
Development 2016;143:398
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Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.
Authors: Dasgupta Et al.
PLoS One 2015;10:e0145333
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All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation.
Authors: Zhu Et al.
J Neurosci 2015;10:e0143255
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Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Authors: Dasgupta Et al.
PLoS One 2014;9:e103604
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Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
Authors: Dobrikov Et al.
Mol Cell Biol 2014;34:439
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