Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Biological ActivityPX 12 is a thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides.
Kirkpatrick et al.
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation.
Welsh et al.
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
Jordan et al.
Clin.Cancer Res., 2005;11:529
Citations for PX 12
The citations listed below are publications that use Tocris products. Selected citations for PX 12 include:
2 Citations: Showing 1 - 2
PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin Et al.
Oncol Lett 2013;6:1804
BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
Authors: Zhu Et al.
Cell Death Differ 2012;31:31
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