PX 12

  ( 2 citations )    
Product Datasheet
Catalog Number:2954
Alternate Names:IV-2
Chemical Name:2-[(1-Methylpropyl)dithio]-1H-imidazole
Product Details
Citations (2)
Reviews
Biological Activity
Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.
Technical Data
  • M.Wt:
    188.31
  • Formula:
    C7H12N2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    141400-58-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PX 12 include:

2 Citations: Showing 1 - 2
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  1. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
    Authors: Shin Et al.
    Oncol Lett  2013;6:1804
  2. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
    Authors: Zhu Et al.
    Cell Death Differ  2012;31:31

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