Catalog Number: 2954
Alternate Names: IV-2
Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Biological Activity
Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.
Technical Data
  • M.Wt:
    188.31
  • Formula:
    C7H12N2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    141400-58-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides.
    Kirkpatrick et al.
    Biochem.Pharmacol., 1998;55:987
  2. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation.
    Welsh et al.
    Mol.Cancer.Ther., 2003;2:235
  3. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
    Jordan et al.
    Clin.Cancer Res., 2005;11:529
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PX 12 include:

1 Citations: Showing 1 - 1

  1. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
    Authors: Zhu Et al.
    Cell Death Differ 2012;31:31

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