PX 12

Catalog # Availability Size / Price Qty
2954/10
2954/50
PX 12 | CAS No. 141400-58-0 | Other Reductase Inhibitors
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Description: Thioredoxin-1 inhibitor
Alternative Names: IV-2

Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Technical Data

M.Wt:
188.31
Formula:
C7H12N2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
141400-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for PX 12

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