Pyr3 (CAS 1160514-60-2): R&D Systems
Catalog Number: 3751
Chemical Name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Biological Activity
Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
Technical Data
  • M.Wt:
    456.63
  • Formula:
    C16H11Cl3F3N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1160514-60-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
    Kiyonaka et al.
    Proc.Natl.Acad.Sci., 2009;106:5400
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pyr3 include:

2 Citations: Showing 1 - 2
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  1. Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
    Authors: Szteyn Et al.
    Am J Physiol Regul Integr Comp Physiol 2015;7
  2. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
    Authors: Senadheera Et al.
    ACS Chem Neurosci 2013;305:R917

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