Pyr3

Catalog # Availability Size / Price Qty
3751/10
3751/50
Cat.No. 3751 - Pyr3 | C16H11Cl3F3N3O3 | CAS No. 1160514-60-2
1 Image
Description: Selective TRPC3 blocker

Chemical Name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Purity: ≥98%

Product Details
Citations (4)
Reviews (1)

Biological Activity

Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

Technical Data

M.Wt:
456.63
Formula:
C16H11Cl3F3N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1160514-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
    Kiyonaka et al.
    Proc.Natl.Acad.Sci., 2009;106:5400

Product Datasheets

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Citations for Pyr3

The citations listed below are publications that use Tocris products. Selected citations for Pyr3 include:

4 Citations: Showing 1 - 4

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Pyr3, a selective TRPC3 channel blocker in mesangial cell
By Hitesh Soni on 01/04/2018
Species: Mouse

For in vitro study to block the TRP ion channel and elucidate the mechanism of proliferation of mesangial cells under normal and high glucose conditions and to understand the role of TRP ion channels in diabetic nephropathy.

PMID: 29273760 Reference

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