Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+
= 0.7 μ
M) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
Kiyonaka et al.
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