Pyr3

  ( 3 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3751
Chemical Name:1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Product Details
Citations (3)
Reviews
Biological Activity
Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
Technical Data
  • M.Wt:
    456.63
  • Formula:
    C16H11Cl3F3N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1160514-60-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pyr3 include:

3 Citations: Showing 1 - 3
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  1. Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
    Authors: Szteyn Et al.
    Am J Physiol Regul Integr Comp Physiol  2015;7
  2. Cerebellar modules operate at different frequencies.
    Authors: Zhou Et al.
    Elife  2014;3:e02536
  3. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
    Authors: Senadheera Et al.
    ACS Chem Neurosci  2013;305:R917

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Average Rating: 5 (Based on 1 review)

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  Mouse Hitesh Soni 01/04/2018
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Species Mouse
Pub Med ID 29273760

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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