Chemical Name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Biological ActivityPyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
Kiyonaka et al.
Citations for Pyr3
The citations listed below are publications that use Tocris products. Selected citations for Pyr3 include:
4 Citations: Showing 1 - 4
Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
Authors: Szteyn Et al.
Am J Physiol Regul Integr Comp Physiol 2015;7
Cerebellar modules operate at different frequencies.
Authors: Zhou Et al.
TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
Authors: Lee Et al.
J Neurosci 2013;33:1157
Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
Authors: Senadheera Et al.
ACS Chem Neurosci 2013;305:R917
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For in vitro study to block the TRP ion channel and elucidate the mechanism of proliferation of mesangial cells under normal and high glucose conditions and to understand the role of TRP ion channels in diabetic nephropathy.