Chemical Name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Biological ActivityPyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
Kiyonaka et al.
Citations for Pyr3
The citations listed below are publications that use Tocris products. Selected citations for Pyr3 include:
4 Citations: Showing 1 - 4
Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
Authors: Szteyn Et al.
Am J Physiol Regul Integr Comp Physiol 2015;7
Cerebellar modules operate at different frequencies.
Authors: Zhou Et al.
TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
Authors: Lee Et al.
J Neurosci 2013;33:1157
Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
Authors: Senadheera Et al.
ACS Chem Neurosci 2013;305:R917
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