Pyrimethamine

Catalog # Availability Size / Price Qty
3918/50
Pyrimethamine | CAS No. 58-14-0 | Multidrug Transporter Inhibitors
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Description: Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor

Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine

Product Details
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Biological Activity

Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

Technical Data

Formula:
C12H13ClN4
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
58-14-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Pyrimethamine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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