Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Biological Activity Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Store at RT
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