Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Biological ActivityPyrimethamine is a potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
Takakura et al.
Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimeth.
Ito et al.
Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimeth. and pyrimeth.
Zimmerman et al.
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