Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (Ki
values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).
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All Tocris products are intended for laboratory research use only.
Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine.
Ito et al.
Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.
Zimmerman et al.