Catalog Number: 4978
Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
Biological Activity
Enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.
    Xu et al.
    Proc.Natl.Acad.Sci.USA, 2010;107:8129
  2. A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.
    Lee et al.
    J.Am.Soc.Nephrol, 2015;
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