Compounds for Stem Cell Proliferation and Renewal: Products

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Y-27632 synthesized to cGMP guidelines

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

SB 431542 synthesized to cGMP guidelines

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin

Selective inhibitor of p38 MAPK

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

MEK inhibitor

FGFR1 and -3 inhibitor

Potent, selective GSK-3 inhibitor

Potent AMPK activator

Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo

Selective PPARγ agonist; antidiabetic agent

Potent GSK-3 inhibitor; also inhibits cdks

Enhances survival of human ESCs following enzymatic dissociation

Potent and selective Lck and Src inhibitor; also inhibits SIK

Broad spectrum ion channel blocker; antiarrhythmic

DYRK1A/B inhibitor

E2F transcription factor inhibitor

CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal

Heparin sulfate antagonist

Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity

Carrier molecule for stem cell culture; replaces serum albumin for ex vivo stem cell expansion

Potent pan-caspase inhibitor

A 83-01 synthesized to Ancillary Material Grade

T3 synthesized to Ancillary Material Grade