PZ-II-029

Key Product Details

Product Description

PZ-II-029 is a GABA_A positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.

Product Specifications for PZ-II-029

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PZ-II-029

The following data is based on the product molecular weight 321.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.11 mL	15.56 mL	31.12 mL
5 mM	0.62 mL	3.11 mL	6.22 mL
10 mM	0.31 mL	1.56 mL	3.11 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fan The α6 subunit-containing GABA_A receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 2018 PMID: 30016665
• Varagic Subtype selectivity of α+β- site ligands of GABA_A receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 2013 PMID: 23472935

Product Documents for PZ-II-029