Recombinant Human QPRT His Protein

Novus Biologicals | Catalog # NBP1-48363

Novus Biologicals
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Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE
View all QPRT Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-297 of Human QPRT

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH

Purity

>95%, by SDS-PAGE

Predicted Molecular Mass

32.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human QPRT His Protein

SDS-PAGE: Recombinant Human QPRT His Protein [NBP1-48363]

SDS-PAGE: Recombinant Human QPRT His Protein [NBP1-48363]

SDS-Page: Recombinant Human QPRT Protein [NBP1-48363] - 15 % SDS-PAGE (3ug)

Formulation, Preparation, and Storage

NBP1-48363
Formulation 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT, 10% glycerol
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: QPRT

Quinolinate phosphoribosyltransferase, also known as QPRT, is a major enzyme in the catabolism of quinolinate. It is an intermediate in the tryptophannicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide and pyrophosphate. Elevation of QPRT levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Recombinant human QPRT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

EC 2.4.2.19, nicotinate-nucleotide pyrophosphorylase (carboxylating), QAPRTase, QPRTasenicotinate-nucleotide pyrophosphorylase [carboxylating], quinolinate phosphoribosyltransferase, Quinolinate phosphoribosyltransferase [decarboxylating]

Gene Symbol

QPRT

Additional QPRT Products

Product Documents for Recombinant Human QPRT His Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Human QPRT His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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