Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Biological ActivityQuercetin is an antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPER) receptors. Blocks cellular entry by influenza A virus via an interaction with hemaglutinin. Inhibits SARS-CoV 3CLpro (IC50 = 73 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium.
Cermak et al.
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo.
Graziani et al.
Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin.
Levy et al.
Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells.
Saponara et al.
Induction of apoptosis by quercetin: involvement of heat shock protein.
Wei et al.
Cancer Res., 1994;54:4952
Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry.
Wu et al.
Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris.
Nguyen et al.
Citations for Quercetin
The citations listed below are publications that use Tocris products. Selected citations for Quercetin include:
3 Citations: Showing 1 - 3
Clobetasol promotes remyelination in a mouse model of neuromyelitis optica.
Authors: Yao Et al.
Acta Neuropathol Commun 2016;4:42
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Authors: Rees Et al.
Neurochem Int 2016;12:109
The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.
Authors: Filone Et al.
PLoS Pathog 2014;10:e1003904
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