Biological ActivityQWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
(Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp(Formyl), Phe-3 = Phe-OBzl)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists.
Hagiwara et al.
Dual action of neurokinin-1 antagonists on Mas-related GPCRs.
Azimi et al.
JCI Insight., 2016;1:e89362
Citation for QWF
The citations listed below are publications that use Tocris products. Selected citations for QWF include:
1 Citation: Showing 1 - 1
Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice
Authors: Song and Shim Et al.
Biomol Ther (Seoul) 2021;
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