QWF

Catalog # Availability Size / Price Qty
6642/5
Cat.No. 6642 - QWF | Boc-Gln-D-Trp(Formyl)-Phe-OBzl | CAS No. 126088-82-2
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Description: MRGPRX2 antagonist; also NK1 receptor antagonist
Product Details
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Biological Activity

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

Technical Data

M.Wt:
697.78
Formula:
C38H43N5O8
Sequence:
QWF

(Modifications: Gln-1 = N-terminal Boc, Trp-2 = D-Trp (Formyl), Phe-3 = Phe-OBzl)

Solubility:
Soluble to 10 mg/ml in DMSO
Storage:
Store at -20°C
CAS No:
126088-82-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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