QX 314 chloride
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Biological ActivityMembrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
Stichartz et al.
QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons.
Alreja and Aghajanian
Brain Res., 1994;639:320
Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells.
Perkins and Wong
Citations for QX 314 chloride
The citations listed below are publications that use Tocris products. Selected citations for QX 314 chloride include:
9 Citations: Showing 1 - 9
Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
Authors: Birdsong Et al.
Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine.
Authors: Arvin Et al.
J Vis Exp 2019;143:e58873
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Authors: Collins Et al.
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Authors: Dong Et al.
Cell Rep 2018;24:284
Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
Cold Spring Harb Protoc 2017;2017
Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
Authors: Bell Et al.
Mol Pain 2015;9:115
hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice.
Authors: Cunningham Et al.
Cell Stem Cell 2014;15:559
Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
Authors: Wood Et al.
Front Cell Neurosci 2009;29:12440
DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
Authors: Wang Et al.
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In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.
QX314 was used to block the activities of TRPV1-positive fibers in AEW-induced chronic itch model