QX 314 chloride

Tocris Bioscience | Catalog # 2313

Na+ channel blocker
Tocris Bioscience

Key Product Details

Description

Na+ channel blocker
View all Voltage-gated Sodium Channel Blockers »

Product Description

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Product Specifications for QX 314 chloride

Molecular Weight

298.85

Formula

C16H27N2OCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

CAS Number

5369-03-9

PubChem ID

21462

InChI Key

LLPPOMUAOGMYQI-UHFFFAOYSA-N

SMILES

[Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30 100

Preparing Stock Solutions for QX 314 chloride

The following data is based on the product molecular weight 298.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.73 mL 33.46 mL
5 mM 0.67 mL 3.35 mL 6.69 mL
10 mM 0.33 mL 1.67 mL 3.35 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 91 publications citing the usage of this product.

Product Documents for QX 314 chloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for QX 314 chloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for QX 314 chloride

Customer Reviews for QX 314 chloride (3)

4.3 out of 5
3 Customer Ratings
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4 Stars
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  • Block of sodium channels in vitro
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Arcuate nucleus
    Verified Customer | Posted 12/10/2023
    QX-314 chloride was used to isolate membrane capacitance fluctuations due to release of neurotransmitter vesicles. Picture: fluctuation of a neuron membrane capacitance after electrical series stimulation of neural tissue; intracellular solution contains 5 mM QX-314.
    QX 314 chloride 2313
  • Whole cell recordings with blocked action potentials
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/08/2018
    In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.
    QX 314 chloride 2313
  • QX314+capsaicin blocks c fiber activities
    Name: Jing Feng
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/10/2018
    QX314 should be injected with capsaicin. QX314: 200ug/mouse Capsaicin: 0.1%
    QX314 was used to block the activities of TRPV1-positive fibers in AEW-induced chronic itch model
    QX 314 chloride 2313

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