Catalog Number: 2313
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.
Technical Data
  • M.Wt:
    298.85
  • Formula:
    C16H27N2OCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    5369-03-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
    Stichartz et al.
    J.Gen.Physiol., 1973;62:37
  2. QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons.
    Alreja and Aghajanian
    Brain Res., 1994;639:320
  3. Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells.
    Perkins and Wong
    J.Neurophysiol., 1995;72:911
Citations:

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