QX 314 chloride

Catalog # Availability Size / Price Qty
QX 314 chloride | CAS No. 5369-03-9 | Voltage-gated Sodium Channel Blockers
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Description: Na+ channel blocker

Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

Purity: ≥99%

Product Details
Citations (9)
Reviews (2)

Biological Activity

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for QX 314 chloride

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Whole cell recordings with blocked action potentials
By Anonymous on 05/08/2018
Application: Species: Mouse

In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.

QX314+capsaicin blocks c fiber activities
By Jing Feng on 01/10/2018
Application: Species: Mouse

QX314 was used to block the activities of TRPV1-positive fibers in AEW-induced chronic itch model

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