R 59-022

Key Product Details

Product Description

R 59-022 is a diacylglycerol (DAG) kinase inhibitor (IC₅₀ = 2.8 μM); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.

Product Specifications for R 59-022

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for R 59-022

The following data is based on the product molecular weight 459.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.35 mL	21.76 mL	43.52 mL
2.5 mM	0.87 mL	4.35 mL	8.70 mL
5 mM	0.44 mL	2.18 mL	4.35 mL
25 mM	0.09 mL	0.44 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Nobe Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions. Br.J.Pharmacol. 2004 PMID: 15289283
• Nunn and Watson A diacylglyerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem.J. 1987 PMID: 2821994
• Boonen Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022. Biochim.Biophys.Acta 1993 PMID: 8392381
• de Chaffoy de Courcelles R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J.Biol.Chem. 1985 PMID: 2999135

Product Documents for R 59-022