Catalog Number: 2194
Chemical Name: 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Biological Activity
Diacylglycerol (DAG) kinase inhibitor (IC50 = 2.8 μM); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.
    de Chaffoy de Courcelles et al.
    J.Biol.Chem., 1985;260:15762
  2. A diacylglyerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets.
    Nunn and Watson
    Biochem.J., 1987;243:809
  3. Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022.
    Boonen et al.
    Biochim.Biophys.Acta, 1993;1178:97
  4. Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions.
    Nobe et al.
    Br.J.Pharmacol., 2004;143:166

The citations listed below are publications that use Tocris products. Selected citations for R 59-022 include:

Showing Results 1 - 1 of 1

  1. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
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