Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50
values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ
= 4.1 μ
M). Also shown to inhibit amyloid-β
production in N2A-APP695
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All Tocris products are intended for laboratory research use only.
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.
Oumata et al.
The citations listed below are publications that use Tocris products. Selected citations for (R)-DRF053 dihydrochloride include:
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