(R)-(-)-Ketamine hydrochloride

Catalog # Availability Size / Price Qty
(R)-(-)-Ketamine hydrochloride | CAS No. 33795-24-3 | NMDA Receptor Antagonists
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Description: NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine

Chemical Name: (R)-(-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride

Purity: ≥99%

Product Details

Biological Activity

(R)-(-)-Ketamine hydrochloride is a NMDA antagonist (Ki = 1.4 μM); exhibits more potent and longer lasting antidepressant effects compared to its enantiomer (S)-ketamine in vivo. Also may not display the psychotomimetic or addictive side effects associated with (S)-ketamine. (R)-(-)-Ketamine hydrochloride upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. It exerts its sustained antidepressant effetcs via KCNQ2 cell type specific regulation.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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