(R)-(-)-Ketamine hydrochloride

Key Product Details

Product Description

(R)-(-)-Ketamine hydrochloride is a NMDA antagonist (K_i = 1.4 μM); exhibits more potent and longer lasting antidepressant effects compared to its enantiomer (S)-ketamine in vivo. Also may not display the psychotomimetic or addictive side effects associated with (S)-ketamine. (R)-(-)-Ketamine hydrochloride upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. It exerts its sustained antidepressant effetcs via KCNQ2 cell type specific regulation.

Product Specifications for (R)-(-)-Ketamine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (R)-(-)-Ketamine hydrochloride

The following data is based on the product molecular weight 274.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.24 mL	36.47 mL
5 mM	0.73 mL	3.65 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.65 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lopez Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 2022 PMID: 35649415
• Ebert Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 1997 PMID: 9311667
• Xiong Comparison of rapid and long-lasting antidepressant effects of negative modulators of α5-containing GABA_A receptors and (R)-ketamine in a chronic social defeat stress model. Pharmacol.Biochem.Behav. 2018 PMID: 30359627
• Zanos NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 2016 PMID: 27144355
• Zhang R-(-)-ketamine shows greater potency and longer lasting antidepressant effects than S-(+)-ketamine. Pharmacol.Biochem.Behav. 2014 PMID: 24316345

Product Documents for (R)-(-)-Ketamine hydrochloride