(R)-(+)-Etomoxir sodium salt

Tocris Bioscience | Catalog # 4539

Carnitine palmitoyltransferase I (CPT1) inhibitor
Tocris Bioscience

Key Product Details

Description

Carnitine palmitoyltransferase I (CPT1) inhibitor
View all Other Transferase Inhibitors »

Product Description

(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Product Specifications for (R)-(+)-Etomoxir sodium salt

Molecular Weight

320.74

Formula

C15H18ClNaO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt

CAS Number

828934-41-4

PubChem ID

57345784

InChI Key

RPACBEVZENYWOL-XFULWGLBSA-M

SMILES

[Na+].[O-]C(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.41 20
DMSO 6.41 20 with gentle warming

Preparing Stock Solutions for (R)-(+)-Etomoxir sodium salt

The following data is based on the product molecular weight 320.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.59 mL 77.94 mL 155.89 mL
1 mM 3.12 mL 15.59 mL 31.18 mL
2 mM 1.56 mL 7.79 mL 15.59 mL
10 mM 0.31 mL 1.56 mL 3.12 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for (R)-(+)-Etomoxir sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-(+)-Etomoxir sodium salt

For research use only

Citations for (R)-(+)-Etomoxir sodium salt

Customer Reviews for (R)-(+)-Etomoxir sodium salt (4)

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  • Very effective for CPT-1 inhibiton
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MCF7
    Verified Customer | Posted 03/27/2020
    MCF7 cells were pretreated with or without 25, 50 μmol/L Etomoxir for 24 h.
    (R)-(+)-Etomoxir sodium salt 4539
  • Efficiently blocks FA catabolism in cell culture
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: 293T
    Verified Customer | Posted 01/27/2020
    Etomoxir shows good solubility profile when diluted from 20 mM stock in DMSO. Does not cause cell death across cell lines at 20 uM.
    Product was diluted to 20 uM in tissue culture and various cancer cells were treated for 18-30 h at this concentration. Enzyme activity was measured by flow cytometry after. Results were strongly replicable.
    (R)-(+)-Etomoxir sodium salt 4539
  • etomoxir was used as a CPT1 inhibitor
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 10/05/2018
    Etomoxir was used as a CPT1 inhibitor in endothelial cells. The data was shown in the publication PubMed ID 29429925.
  • CPT1 inhibition
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: acute brain slice
    Verified Customer | Posted 01/04/2018
    Pre-incubation of 15 minutes at 100 uM
    Exogenous application on acute brain slices

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