Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Biological Activity(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
Ohsawa et al.
Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
Owens et al.
Stereospecific binding of the antidepressant rolipram to brain protein structures.
Schneider et al.
Citation for (R)-(-)-Rolipram
The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Rolipram include:
1 Citation: Showing 1 - 1
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
Authors: Boomkamp Et al.
Br J Pharmacol 2014;171:2385
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
Reviews for (R)-(-)-Rolipram
There are currently no reviews for this product. Be the first to review (R)-(-)-Rolipram and earn rewards!
Have you used (R)-(-)-Rolipram?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image