Catalog Number: 0905
Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram and (S)-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).
Technical Data
  • M.Wt:
    275.35
  • Formula:
    C16H21NO3
  • Solubility:
    Soluble to 75 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    61413-54-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil.
    Kato et al.
    Eur.J.Pharmacol., 1995;272:107
  2. Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate.
    O'Donnell
    J.Pharmacol.Exp.Ther., 1993;264:1168
  3. Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
    Teixeira et al.
    Trends Pharmacol.Sci., 1997;18:164
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rolipram include:

12 Citations: Showing 1 - 10
Filter your results:

  1. β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.
    Authors: Pecha Et al.
    PLoS One 2015;3:e00168
  2. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci 2015;35:621
  3. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Pharmacol Res Perspect 2015;35:396
  4. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci 2015;2
  5. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Eneuro 2015;1853:1749
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    PLoS One 2015;10:e0132884
  7. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
    Authors: Ørstavik Et al.
    J Biol Chem 2015;10:e0115547
  8. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
    Neuropharmacology 2013;67:476
  9. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
    Authors: Morales-Garcia Et al.
    PLoS One 2011;6:e17240
  10. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
    Authors: Adderley Et al.
    Microcirculation 2011;18:128
  11. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    Biochim Biophys Acta 2010;30:12733
  12. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Pharmacol Exp Ther 2002;277:31459
Expand to show all 12 Citations
Tocris Small Molecules
Description Application Cat# Citations Images  

(R)-(-)-Rolipram

1349 1  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

(S)-(+)-Rolipram

1350 4  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used Rolipram?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information