Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Biological ActivityRolipram is a selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.
R-enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil.
Kato et al.
Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate.
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
Teixeira et al.
Trends Pharmacol.Sci., 1997;18:164
Citations for Rolipram
The citations listed below are publications that use Tocris products. Selected citations for Rolipram include:
20 Citations: Showing 1 - 10
Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.
Authors: Franchini Et al.
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4.
Authors: Russo Et al.
J Neuroinflammation 2018;15:297
Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Authors: Ikezu Et al.
J Neuroimmune Pharmacol 2018;13:254
β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.
Authors: Pecha Et al.
PLoS One 2015;3:e00168
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Authors: Zhu Et al.
J Neurosci 2015;35:621
PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
Authors: Choi Et al.
Pharmacol Res Perspect 2015;35:396
MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
Authors: Lundegaard Et al.
Chem Biol 2015;22:1335
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
J Neurosci 2015;2
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
Authors: Parnell Et al.
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Authors: Merino Et al.
PLoS One 2015;10:e0132884
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
Authors: Ørstavik Et al.
J Biol Chem 2015;10:e0115547
Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
Authors: Orru Et al.
Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
Authors: Townsend and Emala
Am J Physiol Lung Cell Mol Physiol 2013;305:L396
Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells.
Authors: Adderley Et al.
Front Pharmacol 2012;3:10
Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference.
Authors: Zhong Et al.
Phosphodiesterase 7 inhibition preserves DArgic neurons in cellular and rodent models of Parkinson disease.
Authors: Morales-Garcia Et al.
PLoS One 2011;6:e17240
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
Authors: Adderley Et al.
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Authors: Schapitz Et al.
Biochim Biophys Acta 2010;30:12733
Identification of a novel human eicosanoid receptor coupled to G(i/o).
Authors: Hosoi Et al.
J Pharmacol Exp Ther 2002;277:31459
A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
Br J Pharmacol 2000;130:685
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