Rolipram

Key Product Details

Product Description

Rolipram is a selective inhibitor of cAMP phosphodiesterase (PDE4) (IC₅₀ = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

R-enantiomer also available.

Product Specifications for Rolipram

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rolipram

The following data is based on the product molecular weight 275.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

19 18 17 16 15 14 13 12 11 10 9 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.84 mL	24.21 mL	48.42 mL
3.75 mM	0.97 mL	4.84 mL	9.68 mL
7.5 mM	0.48 mL	2.42 mL	4.84 mL
37.5 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 159 publications citing the usage of this product.

• O'Donnell Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate. J.Pharmacol.Exp.Ther. 1993 PMID: 8383740
• Teixeira Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol.Sci. 1997 PMID: 9184477
• Kato Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur.J.Pharmacol. 1995 PMID: 7713141

Product Documents for Rolipram