Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50
= 2.0 μ
M). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram
are available (Cat. Nos. 1349 and 1350 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil.
Kato et al.
Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate.
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
Teixeira et al.
Trends Pharmacol.Sci., 1997;18:164
The citations listed below are publications that use Tocris products. Selected citations for Rolipram include:
Showing Results 1 - 10 of 12