Catalog # Availability Size / Price Qty
Rolipram | CAS No. 61413-54-5 | Phosphodiesterase Inhibitors
1 Image
Description: PDE4 inhibitor

Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

Purity: ≥98%

Product Details
Citations (20)
Supplemental Products

Biological Activity

Rolipram is a selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

R-enantiomer also available.

Technical Data

Soluble to 75 mM in DMSO and to 75 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Rolipram

The citations listed below are publications that use Tocris products. Selected citations for Rolipram include:

20 Citations: Showing 1 - 10

  1. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.
    Authors: Franchini Et al.
    iScience  2019;19:927
  2. Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4.
    Authors: Russo Et al.
    J Neuroinflammation  2018;15:297
  3. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
    Authors: Ikezu Et al.
    J Neuroimmune Pharmacol  2018;13:254
  4. β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.
    Authors: Pecha Et al.
    PLoS One  2015;3:e00168
  5. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci  2015;35:621
  6. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Pharmacol Res Perspect  2015;35:396
  7. MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
    Authors: Lundegaard Et al.
    Chem Biol  2015;22:1335
  8. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  9. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Eneuro  2015;1853:1749
  10. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
    Authors: Merino Et al.
    PLoS One  2015;10:e0132884
  11. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
    Authors: Ørstavik Et al.
    J Biol Chem  2015;10:e0115547
  12. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
    Neuropharmacology  2013;67:476
  13. Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
    Authors: Townsend and Emala
    Am J Physiol Lung Cell Mol Physiol  2013;305:L396
  14. Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells.
    Authors: Adderley Et al.
    Front Pharmacol  2012;3:10
  15. Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference.
    Authors: Zhong Et al.
    Neuropsychopharmacology  2012;37:2377
  16. Phosphodiesterase 7 inhibition preserves DArgic neurons in cellular and rodent models of Parkinson disease.
    Authors: Morales-Garcia Et al.
    PLoS One  2011;6:e17240
  17. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
    Authors: Adderley Et al.
    Microcirculation  2011;18:128
  18. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    Biochim Biophys Acta  2010;30:12733
  19. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Pharmacol Exp Ther  2002;277:31459
  20. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
    Authors: Haynes
    Br J Pharmacol  2000;130:685


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Tocris Small Molecules

Reviews for Rolipram

There are currently no reviews for this product. Be the first to review Rolipram and earn rewards!

Have you used Rolipram?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.