Rolipram

  ( 17 citations )    
Product Datasheet
Catalog Number:0905
Chemical Name:4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Product Details
Citations (17)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

R-enantiomer and S-enantiomer also available.

Technical Data
  • M.Wt:
    275.35
  • Formula:
    C16H21NO3
  • Solubility:
    Soluble to 75 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    61413-54-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rolipram include:

17 Citations: Showing 1 - 10
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  1. β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.
    Authors: Pecha Et al.
    PLoS One  2015;3:e00168
  2. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci  2015;35:621
  3. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Pharmacol Res Perspect  2015;35:396
  4. MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
    Authors: Lundegaard Et al.
    Chem Biol  2015;22:1335
  5. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  6. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
    Eneuro  2015;1853:1749
  7. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    PLoS One  2015;10:e0132884
  8. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
    Authors: Ørstavik Et al.
    J Biol Chem  2015;10:e0115547
  9. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
    Neuropharmacology  2013;67:476
  10. Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
    Authors: Townsend and Emala
    Am J Physiol Lung Cell Mol Physiol  2013;305:L396
  11. Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells.
    Authors: Adderley Et al.
    Front Pharmacol  2012;3:10
  12. Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference.
    Authors: Zhong Et al.
    Neuropsychopharmacology  2012;37:2377
  13. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
    Authors: Morales-Garcia Et al.
    PLoS One  2011;6:e17240
  14. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
    Authors: Adderley Et al.
    Microcirculation  2011;18:128
  15. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    Biochim Biophys Acta  2010;30:12733
  16. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Pharmacol Exp Ther  2002;277:31459
  17. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
    Authors: Haynes
    Br J Pharmacol  2000;130:685
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