Catalog Number: 0905
Chemical Name: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC50 = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes. Separate isomers (R)-(-)-Rolipram and (S)-(+)-Rolipram are available (Cat. Nos. 1349 and 1350 respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO and to 75 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil.
    Kato et al.
    Eur.J.Pharmacol., 1995;272:107
  2. Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behaviour maintained by differential reinforcement of low response rate.
    J.Pharmacol.Exp.Ther., 1993;264:1168
  3. Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
    Teixeira et al.
    Trends Pharmacol.Sci., 1997;18:164

The citations listed below are publications that use Tocris products. Selected citations for Rolipram include:

Showing Results 1 - 10 of 12

  1. β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.
    Authors: Pecha Et al.
    PLoS One
  2. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci
  3. PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
    Authors: Choi Et al.
    Pharmacol Res Perspect
  4. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci
  5. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
    Authors: Parnell Et al.
  6. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    PLoS One
  7. The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
    Authors: Ørstavik Et al.
    J Biol Chem
  8. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
  9. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
    Authors: Morales-Garcia Et al.
    PLoS One
  10. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
    Authors: Adderley Et al.
  11. Neuroligin 1 is dynamically exchanged at postsynaptic sites.
    Authors: Schapitz Et al.
    Biochim Biophys Acta
  12. Identification of a novel human eicosanoid receptor coupled to G(i/o).
    Authors: Hosoi Et al.
    J Pharmacol Exp Ther
Expand to show all
Tocris Small Molecules
Description Application Cat# Citations Images  


1349 1  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....


1350 4  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information