Chemical Name: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
Biological ActivityMas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM). Displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. Induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.
Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
Lansu et al.
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