(R)-ZINC 3573

Tocris Bioscience | Catalog # 6351

MRGPRX2 agonist
Tocris Bioscience

Key Product Details

Description

MRGPRX2 agonist
View all Mas-Related G Protein Coupled Receptor Agonists »

Product Description

(R)-ZINC 3573 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM), which displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. (R)-ZINC 3573 induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.

Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of (R)-ZINC 3573 is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for (R)-ZINC 3573

Molecular Weight

307.40

Formula

C18H21N5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

CAS Number

2089389-15-9

PubChem ID

95882507

InChI Key

XKBSPAZCFAIBJL-OAHLLOKOSA-N

SMILES

CN([C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 30.74 100
DMSO 30.74 100

Preparing Stock Solutions for (R)-ZINC 3573

The following data is based on the product molecular weight 307.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for (R)-ZINC 3573

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-ZINC 3573

For research use only

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