(R)-ZINC 3573

Catalog # Availability Size / Price Qty
(R)-ZINC 3573 | CAS No. 2089389-15-9 | Mas-Related G Protein Coupled Receptor Agonists
1 Image
Description: MRGPRX2 agonist

Chemical Name: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

Product Details

Biological Activity

Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM). Displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. Induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.

Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.

Technical Data

Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In silico design of novel probes for the atypical opioid receptor MRGPRX2.
    Lansu et al.
    Nat.Chem.Biol., 2017;13:529

Product Datasheets

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