(R)-ZINC 3573 New
Chemical Name: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
Biological ActivityMas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM). Displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. Induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.
Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
Lansu et al.
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