Raclopride

Catalog # Availability Size / Price Qty
1810/10
1810/50
Raclopride | CAS No. 84225-95-6 | Non-selective Dopamine Receptor Antagonists
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Description: Potent and selective D2 and D3 antagonist

Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products
Reviews (1)

Biological Activity

Selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
347.24
Formula:
C15H20Cl2N2O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
84225-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Animal pharmacology of raclopride, a selective DA D2 antagonist.
    Hall et al.
    Psychopharmacol.Ser., 1989;7:123
  2. The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions.
    Ogren et al.
    Psychopharmacology, 1986;90:287
  3. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264

Product Datasheets

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Citations for Raclopride

The citations listed below are publications that use Tocris products. Selected citations for Raclopride include:

11 Citations: Showing 1 - 10

  1. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
    Authors: Lassus Et al.
    Sci Rep  2018;8:17461
  2. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  3. The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
    Authors: Scardochio Et al.
    Front Behav Neurosci  2015;9:331
  4. Motivational assessment of mice using the touchscreen operant testing system: effects of DArgic drugs.
    Authors: Heath Et al.
    Psychopharmacology (Berl)  2015;232:4043
  5. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
    Authors: Jiang Et al.
    Psychopharmacology (Berl)  2015;18
  6. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
    Authors: Chiodi Et al.
    Neuropsychopharmacology  2014;39:569
  7. Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    J Neurosci  2014;306:R138
  8. DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  9. DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.
    Authors: Ogata Et al.
    J Comp Neurol  2012;520:4032
  10. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
    Authors: Huang Et al.
    Neuropsychopharmacology  2009;34:1979
  11. Increased DA level enhances male-male courtship in Drosophila.
    Authors: Liu Et al.
    Int J Neuropsychopharmacol  2008;28:5539

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Works as intended
By Anonymous on 05/14/2019
Species: Mouse

Used at a range of doses to block dopamine D2 receptors in vivo to test effect on alcohol-cue learning and seeking behavior. Drug performed well and although didn't impact place preference it did have a clear effect in that it dose-dependently decrease locomotor activity.

PMID: 24005528

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