Raclopride

  ( 9 citations )    
Product Datasheet
Catalog Number:1810
Chemical Name:3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    347.24
  • Formula:
    C15H20Cl2N2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    84225-95-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Raclopride include:

9 Citations: Showing 1 - 9
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  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  2. The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
    Authors: Scardochio Et al.
    Front Behav Neurosci  2015;9:331
  3. Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs.
    Authors: Heath Et al.
    Psychopharmacology (Berl)  2015;232:4043
  4. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
    Authors: Jiang Et al.
    Psychopharmacology (Berl)  2015;18
  5. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
    Authors: Chiodi Et al.
    Neuropsychopharmacology  2014;39:569
  6. Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    J Neurosci  2014;306:R138
  7. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  8. Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.
    Authors: Ogata Et al.
    J Comp Neurol  2012;520:4032
  9. Increased dopamine level enhances male-male courtship in Drosophila.
    Authors: Liu Et al.
    Int J Neuropsychopharmacol  2008;28:5539

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