Catalog Number: 1810
Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
Biological Activity
Selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    347.24
  • Formula:
    C15H20Cl2N2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    84225-95-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Animal pharmacology of raclopride, a selective dopamine D2 antagonist.
    Hall et al.
    Psychopharmacol.Ser., 1989;7:123
  2. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  3. The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions.
    Ogren et al.
    Psychopharmacology, 1986;90:287
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Raclopride include:

9 Citations: Showing 1 - 9
Filter your results:

  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell 2017;16(6):1323
  2. The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
    Authors: Scardochio Et al.
    Front Behav Neurosci 2015;9:331
  3. Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs.
    Authors: Heath Et al.
    Psychopharmacology (Berl) 2015;232:4043
  4. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
    Authors: Jiang Et al.
    Psychopharmacology (Berl) 2015;18
  5. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
    Authors: Chiodi Et al.
    Neuropsychopharmacology 2014;39:569
  6. Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    J Neurosci 2014;306:R138
  7. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem 2013;
  8. Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.
    Authors: Ogata Et al.
    J Comp Neurol 2012;520:4032
  9. Increased dopamine level enhances male-male courtship in Drosophila.
    Authors: Liu Et al.
    Int J Neuropsychopharmacol 2008;28:5539

Have you used Raclopride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information