Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
Biological ActivityRaclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Animal pharmacology of raclopride, a selective DA D2 antagonist.
Hall et al.
The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions.
Ogren et al.
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
Citations for Raclopride
The citations listed below are publications that use Tocris products. Selected citations for Raclopride include:
12 Citations: Showing 1 - 10
Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.
Authors: Verharen Et al.
Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
Authors: Lassus Et al.
Sci Rep 2018;8:17461
DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Aging Cell 2017;16(6):1323
The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
Authors: Scardochio Et al.
Front Behav Neurosci 2015;9:331
Motivational assessment of mice using the touchscreen operant testing system: effects of DArgic drugs.
Authors: Heath Et al.
Psychopharmacology (Berl) 2015;232:4043
SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
Authors: Jiang Et al.
Psychopharmacology (Berl) 2015;18
Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.
Authors: Chiodi Et al.
Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
Authors: Zheng Et al.
J Neurosci 2014;306:R138
DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
Authors: Ahmadiantehrani and Ron
J Neurochem 2013;
DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.
Authors: Ogata Et al.
J Comp Neurol 2012;520:4032
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Authors: Huang Et al.
Increased DA level enhances male-male courtship in Drosophila.
Authors: Liu Et al.
Int J Neuropsychopharmacol 2008;28:5539
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Used at a range of doses to block dopamine D2 receptors in vivo to test effect on alcohol-cue learning and seeking behavior. Drug performed well and although didn't impact place preference it did have a clear effect in that it dose-dependently decrease locomotor activity.