Biological ActivityRAGE antagonist peptide is a receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.
(Modifications: Glu-1 = N-terminal Ac, Leu-10 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis.
Clin. Cancer Res., 2012;18(16):4356-64.
The receptor for advanced glycation end products is required for �-catenin stabilization in a chemical-induced asthma model.
Yao et al.
Citations for RAGE antagonist peptide
The citations listed below are publications that use Tocris products. Selected citations for RAGE antagonist peptide include:
2 Citations: Showing 1 - 2
Blood-Borne Microparticles Are an Inflammatory Stimulus in Type 2 Diabetes Mellitus
Authors: Thom Et al.
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Authors: Uderhardt Et al.
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