Raloxifene hydrochloride

Key Product Details

Product Description

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC₅₀ of 1 nM.

Product Specifications for Raloxifene hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Raloxifene hydrochloride

The following data is based on the product molecular weight 510.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.92 mL	19.61 mL	39.21 mL
2.5 mM	0.78 mL	3.92 mL	7.84 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Todorova Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 2011 PMID: 20383709
• Bryant Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2001 PMID: 11704975
• Hibner Effects of ralox. hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol.
• Fitzpatrick Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 1999 PMID: 10465261

Product Documents for Raloxifene hydrochloride