Raloxifene hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:2280
Alternate Names:LY 139481, Keoxifene
Chemical Name:[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
Selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM.
Technical Data
  • M.Wt:
    510.04
  • Formula:
    C28H27NO4S.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    82640-04-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Raloxifene hydrochloride include:

1 Citations: Showing 1 - 1

  1. Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
    Authors: Nicholson Et al.
    Am J Physiol Heart Circ Physiol  2015;193:722

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