RANK/TNFRSF11A Antibody - BSA Free

Novus Biologicals | Catalog # NB100-56396

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all RANK/TNFRSF11A Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to amino acid residues 603-613 of human RANK (NP_003830).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RANK/TNFRSF11A Antibody - BSA Free

Western Blot: RANK/TNFRSF11A Antibody [NB100-56396]

Western Blot: RANK/TNFRSF11A Antibody [NB100-56396]

Western Blot: RANK/TNFRSF11A Antibody [NB100-56396] - Analysis of RANK in RAW cell lysate.

Applications for RANK/TNFRSF11A Antibody - BSA Free

Application
Recommended Usage

Western Blot

1-3 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RANK/TNFRSF11A

Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) (mAbs to RANKL are also available) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathway. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2.

Long Name

Receptor Activator of NF-kappa-B

Alternate Names

CD265, ODFR, TNFRSF11A, TRANCE R

Entrez Gene IDs

8792 (Human); 21934 (Mouse)

Gene Symbol

TNFRSF11A

UniProt

Q9Y6Q6

Additional RANK/TNFRSF11A Products

Product Documents for RANK/TNFRSF11A Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for RANK/TNFRSF11A Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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