Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric)

Novus Biologicals | Catalog # KA2007

Novus Biologicals
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Key Product Details

Sample Type & Volume Required Per Well

Cell Culture Supernatant, Serum (100 uL)

Sensitivity

<2 pg/mL

Assay Range

62.5 to 4000 pg/mL
View all RANK/TNFRSF11A ELISA Kits »

Product Specifications

Assay Type

Sandwich ELISA

Kit Type

ELISA Kit (Colorimetric)

Species

Mouse

Description

Tnfrsf11a (Mouse) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of mouse Tnfrsf11a.

Precision

Intra-Assay Precision (Precision within an assay) CV% 6.4%

Inter-Assay Precision (Precision between assays) CV% 5.4%

Scientific Data Images for Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric)

ELISA: Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric) [KA2007]

ELISA: Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric) [KA2007]

ELISA: RANK/TNFRSF11A ELISA Kit [Biotin] [KA2007] - Standard curve

Kit Contents for Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric)

  • 96-well plate precoated with anti- mouse RANK antibody
  • ABC diluent buffer
  • Antibody diluent buffer
  • Avidin-Biotin-Peroxidase Complex (ABC) (dilution 1:100)
  • Biotinylated anti- mouse RANK antibody (dilution 1:100)
  • Lyophilized recombinant mouse RANK standard
  • Sample diluent buffer
  • TMB color developing agent
  • TMB stop solution

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RANK/TNFRSF11A

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family (1). RANK ligand (RANKL/TRANCE/ OPGL) (mAbs to RANKL is also available from Imgenex, Cat # IMG-133) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6 (3,4). Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways (3). Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2 (4).

Long Name

Receptor Activator of NF-kappa-B

Alternate Names

CD265, ODFR, TNFRSF11A, TRANCE R

Gene Symbol

TNFRSF11A

Additional RANK/TNFRSF11A Products

Product Documents for Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric)

Certificate of Analysis

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Product Specific Notices for Mouse RANK/TNFRSF11A ELISA Kit (Colorimetric)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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