Rat Neuropilin-2 Alexa Fluor® 488-conjugated Antibody
Rat Neuropilin-2 Alexa Fluor® 488-conjugated Antibody Summary
Gln23-Asp857 (Val809-Asp825 del)
Accession # O35276
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Neuropilin‑2 in C6 Rat Cell Line by Flow Cytometry. C6 rat glioma cell line was stained with Mouse Anti-Rat Neuropilin‑2 Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB567G, filled histogram) or isotype control antibody (Catalog # IC0041G, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Neuropilin-2 (Npn-2), previously known as Npn-1-related molecule, is a 120-140 kDa type I transmembrane protein that belongs to the neuropilin family of molecules. It binds members of the class III secreted semaphorin subfamily (Sema3C and 3F), multiple VEGFs (VEGF145, VEGF165, VEGF-C and VEGF-D), PlGF, and HGF, and forms complexes with NRP1, Plexin A1,A2, A3, A4 and Plexin B1, plus VEGFR1, 2 and 3, and Integrin alpha 6 beta 1. The extracellular domain of these proteins is composed of two N-terminal CUB (complement-binding) domains (domains a1 and a2), two domains with homology to coagulation factors V and VIII (domains b1 and b2) and a MAM (meprin) domain (domain c). In the absence of ligands, neuropilins can form homo- and hetero-oligomers via homophilic interactions of their MAM domains. At the amino acid (aa) sequence level, Npn-2 shares 96% and 94% aa sequence identity with mouse and human Neuropilin-2, respectively. The expression patterns of Npn-1 and Npn-2 in developing neurons of the central and peripheral nervous systems are largely, though not completely non-overlapping. Npn-2 is expressed by vascular and lymphatic endothelim plus tumor cells, and has been suggested to appear also on macrophages, GABAergic neurons and proximal convoluted tubule cells.
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