Recombinant Human alpha 1B-Glycoprotein Protein, CF
Recombinant Human alpha 1B-Glycoprotein Protein, CF Summary
Ala22-Ser495, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: alpha 1B-Glycoprotein
Alpha-1B-glycoprotein (A1BG) is an approximately 80 kDa molecule that circulates in the serum (1). Mature human A1BG consists of five tandem Ig‑like domains and shares 44% amino acid sequence identity with mouse and rat A1BG (2, 3). Alternative splicing generates an isoform that lacks the signal peptide and the first Ig‑like domain. A1BG binds with high affinity to the cysteine‑rich protein CRISP‑3 (4). In pancreatic carcinoma, it is elevated in pancreatic juice as well as in the serum relative to normal patients (5, 6). A1BG is abnormally excreted into the urine during idiopathic nephrotic syndrome (INS) (7). Multiple breakdown fragments of A1BG are also present in INS urine, including one of 14 kDa that is found in steroid‑resistant but not steroid‑sensitive cases (7). A1BG is also elevated in the urine of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) (8).
- Schultze, H.E. et al. (1963) Nature 200:1103.
- Ishioka, N. et al. (1986) Proc. Natl. Acad. Sci. USA 83:2363.
- Gardmo, C. et al. (2001) Endocrinology 142:2695.
- Udby, L. et al. (2004) Biochemistry 43:12877.
- Tian, M. et al. (2008) BMC Cancer 8:241.
- Li, C. et al. (2009) J. Proteome Res. 8:483.
- Piyaphanee, N. et al. (2011) Proteomics Clin. Appl. 5:334.
- Goo, Y.A. et al. (2010) Int. Braz. J. Urol. 36:464.
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