Recombinant Human Annexin A4 Protein, CF

R&D Systems | Catalog # 9414-AN

R&D Systems
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Key Product Details

  • R&D Systems E. coli-derived Recombinant Human Annexin A4 Protein (9414-AN)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

E. coli

Accession Number

NP_001144
View all Annexin A4 Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human Annexin A4 protein
Ala2-Asp321, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala2

Predicted Molecular Mass

37 kDa

SDS-PAGE

35 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation, and Storage

9414-AN
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Annexin A4

Annexin A4 (ANXA4), also known as Lipocortin IV, placental anticoagulant protein II, and zymogen granule membrane-associated protein of 36 kDa (ZAP36), is a member of the Annexin protein family. Annexins are calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites. The C-terminal domain is comprised of four 60-70 aa annexin repeats which form a tightly packed disc known as the annexin domain. Members of the Annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. (1) Annexin A4 regulates the transcription from RNA polymerase II promoter (2). The level of Annexin A4 increases in cytoplasm during apoptosis (3). Human Annexin A4 shares 92% aa sequence identity with mouse and rat Annexin A4.

References

  1. Gerke, V. et al. (2005) Nat. Rev. Mol. Cell Biol. 6:449.
  2. Jeon, Y. J. et al. (2010). Cellular and molecular life sciences, 67:2271.
  3. Gerner, C. et al. (2000). J. Biol. Chem. 275:39018

Alternate Names

AIV, Annexin IV, ANX4, ANXA4, Lipocortin IV, PIG28, ZAP36

Entrez Gene IDs

307 (Human); 11746 (Mouse); 79124 (Rat)

Gene Symbol

ANXA4

UniProt

NP_001144

Additional Annexin A4 Products

Product Documents for Recombinant Human Annexin A4 Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human Annexin A4 Protein, CF

For research use only

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