Recombinant Human BAMBI/NMA Fc Chimera Protein, CF

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Recombinant Human BAMBI/NMA Fc Chimera Protein, CF Summary

Product Specifications

>90%, by SDS-PAGE with silver staining, under reducing conditions
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its ability to induce cell death using Mv1Lu mink lung epithelial cells. The ED50 for this effect is 1-6 μg/mL.
Mouse myeloma cell line, NS0-derived human BAMBI/NMA protein
Accession # Q13145
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
40.5 kDa (monomer)
45-48 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: BAMBI/NMA

BAMBI (BMP and Activin membrane-bound inhibitor), also called NMA (non-metastatic gene A) is a type I transmembrane protein that shares sequence homology with the TGF‑ beta type I receptor family and functions as a decoy receptor (1). The 260 amino acid (aa) human BAMBI protein contains a 20 aa signal sequence, a 132 aa extracellular domain (ECD) with one potential N‑glycosylation site, a transmembrane domain and a cytoplasmic domain. The human BAMBI ECD shares 91%, 93%, 94%, 94%, 92%, 92% and 92% aa sequence identity with mouse, rat, canine, porcine, equine, ovine and bovine BAMBI, respectively. BAMBI differs from the
TGF-beta  RI family by having a short cytoplasmic region that lacks the kinase domain (1, 2). It competes with type I receptors and forms heterodimers with type II receptors (2). During development, BAMBI is prominent in gastrulation, neurulation, and development of teeth and bones, and is often co‑expressed with BMP family members (1, 2, 4, 6). It antagonizes Activin and TGF‑ beta signaling, and may increase the dynamic range of BMPs to aid in BMP gradient effectiveness (4, 6). In the adult, it modulates processes such as adipogenesis, response to arterial injury, and tumor/tumor stroma promotion by TGF-beta (1, 3, 7, 9‑11). Although it is not expressed in other normal skin cells, it is highly expressed in melanocytes and may be inversely correlated with metastatic potential in melanomas (3). BAMBI is induced by TGF‑ beta and Wnt signaling, and cooperates with inhibitory Smad6 and Smad7 to inhibit TGF‑ beta signaling (5). In contrast, it promotes Wnt signaling (8).

  1. Knight, C. et al. (2001) J. Dent. Res. 80:1895.
  2. Onichtchouk, D. et al. (1999) Nature 401:480.
  3. Degen, W.G. et al. (1996) Int. J. Cancer 65:460.
  4. Paulsen, M. et al. (2011) Proc. Natl. Acad. Sci. USA 108:10202.
  5. Yan, X. et al. (2009) J. Biol. Chem. 284:30097.
  6. Montero, J.A. et al. (2008) Dev. Biol. 321:343.
  7. Guillot, N. et al. (2013) PLoS ONE 8:e58550.
  8. Lin, Z. et al. (2008) J. Biol. Chem. 283:33053.
  9. Luo, X. et al. (2012) Diabetes 61:124.
  10. Shangguan, L. et al. (2012) Stem Cells 30:2810.
  11. Sekiya, T. et al. (2004) J. Biol. Chem. 279:6840.
Long Name
BMP and Activin Membrane-bound Inhibitor
Entrez Gene IDs
25805 (Human); 68010 (Mouse)
Alternate Names
BAMBI; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); BMP and activin membrane-bound inhibitor homolog; NMA; NMANon-metastatic gene A protein; Putative transmembrane protein NMA

Citation for Recombinant Human BAMBI/NMA Fc Chimera Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
    Authors: Devlin, Anna-Cla, Burr, Karen, Borooah, Shyamang, Foster, Joshua D, Cleary, Elaine M, Geti, Imbisaat, Vallier, Ludovic, Shaw, Christop, Chandran, Siddhart, Miles, Gareth B
    Nat Commun, 2015-01-12;6(0):5999.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay


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