Recombinant Human Carbonic Anhydrase VI Protein, CF

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2939-CA-010
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Recombinant Human Carbonic Anhydrase VI Protein, CF Summary

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its esterase activity. The specific activity is >3 pmol/min/µg, as measured under the described conditions.
Source
Mouse myeloma cell line, NS0-derived human Carbonic Anhydrase VI protein
Gln18-Asn308, with a C-terminal 10-His tag
Accession #
N-terminal Sequence
Analysis
No results obtained: Gln18 predicted
Predicted Molecular Mass
35 kDa
SDS-PAGE
42 kDa, reducing conditions

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Background: Carbonic Anhydrase VI

Carbonic Anhydrase catalyzes the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption (1). Topics in a CA meeting (6th International Conference on the CAs, June 20‑25, 2003, Slovakia) ranged from the use of CAs as markers for tumor and hypoxia in the clinic, as a nutritional supplement in milk, and as a tool for CO2 removal and mosquito control in industry. Carbonic Anhydrase VI, also known as gustin and salivary Carbonic Anhydrase, is a zinc-metalloprotein that constitutes about 3% of human parotid saliva protein (2, 3). It was decreased in patients with loss of taste and pathological changes in taste buds (4). It is also an elementary component of milk. It plays an important role in normal growth and development of the infant alimentary tract (5).

References
  1. Hewett-Emmett, D. and R.E. Tashian (1996) Mol. Phylogenet. Evol. 5:50.
  2. Murakami, H. and Sly, W. S. (1987) J. Biol. Chem. 262:1382.
  3. Thatcher, B. J. et al. (1998) Biochem. Biophys. Res. Commun. 250:635.
  4. Hankin, R. I. et al. (1999) Am. J. Med. Sci. 318:380.
  5. Karhumaa, P. et al. (2001) Proc. Natl. Acad. Sci. USA. 98:11604.
Entrez Gene IDs
765 (Human); 298657 (Rat)
Alternate Names
CA6; Carbonate dehydratase VI; carbonic anhydrase 6; Carbonic Anhydrase VI; carbonic anhydrase VIGUSTIN; CA-VI; EC 4.2.1.1; Gustin; MGC21256; Salivary carbonic anhydrase; Secreted carbonic anhydrase

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