Recombinant Human Carbonic Anhydrase X/CA10 Protein, CF

Carbonic Anhydrase (CA) catalyzes the reversible reaction of CO₂ + H₂O = HCO₃^- + H⁺, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption (1). Topics in a CA meeting (6^th International Conference on the CAs, June 20 - 25, 2003, Slovakia) ranged from the use of CAs as markers for tumor and hypoxia in the clinic, as a nutritional supplement in milk, and as a tool for CO₂ removal and mosquito control in industry. CA10, also known as CA-related protein, CA-RA X, is a secreted protein without CA activity (i.e., the reversible hydration of CO₂) due to point mutations in the zinc-binding site. The human and mouse CA10 are expressed in the brain, indicating that they may play a role in brain development (2, 3).