Recombinant Human CL-K1/COLEC11 Protein, CF
Recombinant Human CL-K1/COLEC11 Protein, CF Summary
Gln26-Met271, with a C-terminal 6-His tag
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS and NaCl.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Collectins constitute a family of C-type lectins that recognize molecular patterns expressed on pathogens. Members of this glycoprotein family contain an N-terminal domain, a collagen-like domain, a neck region, and a C-terminal carbohydrate recognition domain (CRD). Collectins are typically secreted molecules, although CL-P1 is membrane bound and CL-L1 is found in the cytoplasm (1 - 3). Collectin kidney 1 (CL-K1), also known as collectin subfamily member 11 (COLEC11), is a 37 kDa collectin that circulates in the blood (4, 5). Alternative splicing may generate multiple isoforms with deletions or substitutions in the N-terminal and collagen-like domains (6). CL-K1 is widely expressed, notably in renal proximal tubules, bronchial glands, and gastrointestinal mucosa (5). It associates into disulfide-linked oligomers and preferentially interacts with fucose residues in a calcium-dependent manner (4). Mature human CL-K1 shares 93% amino acid sequence identity with mouse and rat CL-K1. Within the CRD, human CL-K1 shares 55% aa sequence identity with CL-L1 and 26% - 33% aa sequence identity with collectins CL-P1, MBL, SP-A, and SP-D.
- Gupta, G. and A. Surolia, 2007, Bioessays 29:452.
- van de Wetering, J.K. et al., 2004, Eur. J. Biochem. 271:1229.
- Holmskov, U. et al., 2003, Annu. Rev. Immunol. 21:547.
- Keshi, H. et al., 2006, Microbiol. Immunol. 50:1001.
- Motomura, W. et al., 2008, J. Histochem. Cytochem. 56:243.
- SwissProt # Q9BWP8.
Citation for Recombinant Human CL-K1/COLEC11 Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome.
Authors: Rooryck C, Diaz-Font A, Osborn DP
Nat. Genet., 2011;43(3):197-203.
Sample Types: Whole Cells
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