Recombinant Human Complement Factor H-related 5/CFHR5, CF Summary
Glu19-Glu569, with a C-terminal 10-His tag
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: Complement Factor H-related 5/CFHR5
The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1 (FHL-1) and five factor H-related proteins (FHR-1 to -5) (2). Members of this family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. The genes of this family have been located in human chromosome 1q32, which is known as the regulator of complement activation (RCA) gene clusters (3). FHR-5 has been identified initially as a universal component of complement deposits (1), and detected in glomerular immune deposits (4). The pattern of deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. It is synthesized in the liver and consists of 9 SCRs. Its biological function is not understood fully. FHR-5 exhibits similar characteristics as those of factor H in heparin binding, CRP binding, and lipoprotein association (5). Weak factor I-dependent cofactor activity for C3b cleavage has also been observed (5).
- McRae, J. L. et al. (2001) J. Biol. Chem. 276:6747.
- Zipfel, P. F. et al. (2002) Biochem. Soc. Trans. 30:971.
- McRae, J. L. et al. (2002) Genetica. 114:157.
- Murphy, B. et al. (2002) Am. J. Kidney. Dis. 39:24.
- McRae, J. L. et al. (2005) J. Immunol. 174:6250.
Citations for Recombinant Human Complement Factor H-related 5/CFHR5, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
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Glomerular Complement Factor H-Related Protein 5 is Associated with Histologic Injury in Immunoglobulin A Nephropathy
Authors: WY Guo, LJ Sun, HR Dong, GQ Wang, XY Xu, ZR Zhao, H Cheng
Kidney international reports, 2021;6(2):404-413.
Sample Types: Plasma
Applications: ELISA Control
Glomerular Complement Factor H-Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment
Authors: NR Medjeral-T, H Moffitt, HJ Lomax-Brow, N Constantin, T Cairns, HT Cook, MC Pickering
Kidney Int Rep, 2019;4(10):1387-1400.
Sample Types: Whole Tissue
FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation
Authors: ÁI Csincsi, Z Szabó, Z Bánlaki, B Uzonyi, M Cserhalmi, É Kárpáti, A Tortajada, JJE Caesar, Z Prohászka, TS Jokiranta, SM Lea, S Rodríguez, M Józsi
J. Immunol., 2017;0(0):.
Sample Types: Recombinant Protein
Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.
Authors: Csincsi A, Kopp A, Zoldi M, Banlaki Z, Uzonyi B, Hebecker M, Caesar J, Pickering M, Daigo K, Hamakubo T, Lea S, Goicoechea de Jorge E, Jozsi M
J Immunol, 2015;194(10):4963-73.
Sample Types: Protein
Applications: Binding Assay
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