Recombinant Human Contactin-1 Fc Chimera Protein, CF
Recombinant Human Contactin-1 Fc Chimera Protein, CF Summary
Accession # CAA79696
|IEGRMD||Human IgG1 |
Contactin-1 (CNTN1), also known as F3 and F11, is an approximately 135 kDa GPI-anchored member of the Contactin family of neuronal adhesion glycoproteins (1). Mature human Contactin-1 contains 6 Ig-like domains and 4 fibronectin type III-like domains, and it shares 96% amino acid (aa) sequence identity with mouse and rat Contactin-1 (2, 3). Alternative splicing generates an isoform with an 11 aa deletion N-terminal to the first Ig-like domain and another isoform that is substituted and truncated following the sixth Ig-like domain. A soluble form of Contactin-1 is released into the cerebrospinal fluid (4). Contactin-1 is expressed on neurons and their precursors at sites of glial cell contact with neuronal processes (5-7). Within paranodal regions of the axon, Contactin-1 associates in cis with the transmembrane protein Caspr (7). It binds in trans to other neuronal adhesion proteins (e.g. NrCAM, Neurofascin, Tenascin R), the phosphatase PTPRZ, and the chondroitin sulfate CS-E (8-13). It also binds and activates both Notch-1 and Notch-2 (14). Ligation of Contactin-1 promotes neurite outgrowth, adhesion to Schwann cells, axon myelination, and differentiation of oligodendrocytes and cerebellar granule neurons, but it can also negatively regulate neurogenesis in the ventricular zone
(4, 6-9, 12-14). In cancer, Contactin-1 is up-regulated by VEGF-C and is required for VEGF R3/Flt-4 induced tumor cell invasion and metastasis (15).
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Citation for Recombinant Human Contactin-1 Fc Chimera Protein, CF
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1 Citation: Showing 1 - 1
Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage.
Authors: Leite C, Silva N, Mendes S, Ribeiro A, de Faria J, Lourenco T, dos Santos F, Andrade P, Cardoso C, Vieira M, Paiva A, da Silva C, Cabral J, Relvas J, Graos M
PLoS ONE, 2014;9(10):e111059.
Sample Types: Whole Cells
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