Recombinant Human CSMD3 Protein, CF Summary
Ala2218-Ser3306, with a C-terminal 6-His tag
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some researchers may wish to use polypeptides to make antibodies. To facilitate the advancement of new science, we now offer our Innovator Series of proteins.
CSMD3 is a new member of CSMD (CUB and sushi multiple domains) gene family. The CSMD3 gene codes a protein of 406 kDa consisting of 3707 amino acids (aa). The CSMD3 molecule is a transmembrane protein composed of a long N-terminal polypeptide with CUB and sushi multiple domains exposing outside the cell, a single transmembrane domain, and a C-terminal domain of 55 aa located in the cytoplasm (1). CSMD3 is expressed at low levels in many tissues with highest expression in fetal and adult brains (2). Little is known about the potential function of CSMS3. CUB and sushi domains are thought to be sites of protein‑protein or protein-ligand interactions, suggesting that CSMD3 protein is either a transmembrane receptor or adhesion molecule (3, 4). The other two members of CSMD family are CSMD1 and CSMD2. CSMD1 was reproted as a candidate suppressor of head and neck squamous cell carcinomas (5). It is suspected that CSMD3 could also function as a tumor suppressor.
- Shimizu, A. et al. (2003) Biochem. Biophy. Res. Commun. 309:143.
- Lau, W.L. and S.B. Scholnick (2003) Genomics 82:412.
- Bork, P. and G. Beckmann (1993) J. Mol. Biol. 231:539.
- Norman, D.G. et al. (1991) J. Mol. Biol. (1991) 219:717.
- Sun, P.C. et al. (2001) Genomics 75:17.
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