Recombinant Human CSMD3 Protein, CF

R&D Systems | Catalog # 9689-CS

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Key Product Details

  • R&D Systems CHO-derived Recombinant Human CSMD3 Protein (9689-CS)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

CHO

Accession Number

Q7Z407-1
View all CSMD3 Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human CSMD3 protein
Ala2218-Ser3306, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala2218 & Tyr2219

Predicted Molecular Mass

119 kDa

SDS-PAGE

120-147 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation, and Storage

9689-CS
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution

Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: CSMD3

CSMD3 is a new member of CSMD (CUB and sushi multiple domains) gene family. The CSMD3 gene codes a protein of 406 kDa consisting of 3707 amino acids (aa). The CSMD3 molecule is a transmembrane protein composed of a long N-terminal polypeptide with CUB and sushi multiple domains exposing outside the cell, a single transmembrane domain, and a C-terminal domain of 55 aa located in the cytoplasm (1). CSMD3 is expressed at low levels in many tissues with highest expression in fetal and adult brains (2). Little is known about the potential function of CSMS3. CUB and sushi domains are thought to be sites of protein‑protein or protein-ligand interactions, suggesting that CSMD3 protein is either a transmembrane receptor or adhesion molecule (3, 4). The other two members of CSMD family are CSMD1 and CSMD2. CSMD1 was reproted as a candidate suppressor of head and neck squamous cell carcinomas (5). It is suspected that CSMD3 could also function as a tumor suppressor.

References

  1. Shimizu, A. et al. (2003) Biochem. Biophy. Res. Commun. 309:143.
  2. Lau, W.L. and S.B. Scholnick (2003) Genomics 82:412.
  3. Bork, P. and G. Beckmann (1993) J. Mol. Biol. 231:539.
  4. Norman, D.G. et al. (1991) J. Mol. Biol. (1991) 219:717.
  5. Sun, P.C. et al. (2001) Genomics 75:17.

Long Name

CUB And Sushi Multiple Domains 3

Alternate Names

CSMD-3, KIAA1894

Entrez Gene IDs

114788 (Human); 239420 (Mouse); 314942 (Rat)

Gene Symbol

CSMD3

UniProt

Q7Z407-1

Additional CSMD3 Products

Product Documents for Recombinant Human CSMD3 Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human CSMD3 Protein, CF

For research use only

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