Recombinant Human EGF-L6 Protein, CF Summary
Accession # Q8IUX8
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in MES and NaCl.|
|Reconstitution||Reconstitute at 500 μg/mL in PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Epidermal Growth Factor-like Domain, Multiple 6 (EGF-L6), also known as MAM- and EGF-containing (MAEG) is a member of the EGF repeat superfamily of proteins. This secreted protein contains five EGF-like repeats, an RGD motif that binds to Integrin alpha 8 beta 1, and a C-terminal MAM domain (1, 2). Within shared regions, human EGF-L6 shares 75% and 78% amino acid sequence identity with the mouse and rat orthologs, respectively. EGF-L6 is expressed in a multitude of fetal tissues during early development such as lung, heart, liver, spleen, cochlea, and placenta (3, 4). It is also expressed in the dermatome and dermatome-derived tissues including trunk dermis, hair follicles, and cranio-facial mesenchyme (5). EGF-L6 is expressed by osteoblastic-like cells and has been shown to act in a paracrine manner to promote migration of vascular endothelial cells, thus regulating angiogenesis in the local environment of the bone (4, 6). Additionally, EGF-L6 is expressed by epidermal stem cells in the hair follicle bulge and is believed to play a role in regulating the dermal vasculature (7). EGF-L6 is also produced by mature adipocytes and is thought to be involved in the process of adipose tissue expansion and the development of obesity (8). EGF-L6 expression is increased in fibroblastic meningioma and ovarian cancer and has been proposed as a biomarker for the latter (9, 10).
- Buchner, G. et al. (2000) Genomics 65:16.
- Osada, A. et al. (2005) Exp. Cell Res. 303:148.
- Yeung, G. et al. (1999) Genomics 62:304.
- Chim, S.M. et al. (2011) J. Biol. Chem. 286:22035.
- Buchner, G. et al. (2000) Mech. Dev. 98:179.
- Chim, S.M. et al. (2013) Cytokine Growth Factor Rev. 24:297.
- Xiao, Y. et al. (2013) J. Invest. Dermatol. 133:2324.
- Oberauer, R. et al. (2010) Mol. Cell. Biochem. 343:257.
- Buckanovich, R.J. et al. (2007) J. Clin. Oncol. 25:852.
- Wang, X. et al. (2012) PLoS ONE 7:e52707.
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