Recombinant Human Erythropoietin R Fc Chimera Protein, CF Summary
|Human Epo R
Accession # P19235
|IEGRMD||Human IgG1 |
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CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Background: Erythropoietin R
Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The biological effects of EPO are mediated by the erythropoietin receptor (EPO R). The genes for human and mouse EPO R have been cloned and characterized. The full-length human EPO R cDNA encodes a type I membrane-spanning protein with 508 amino acid (aa) residues (a 24 aa residue hydrophobic signal sequence, a 226 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 236 aa residue cytoplasmic domain). At the protein sequence level, the human EPO R is approximately 82% identical to the mouse protein. As a result of alternative splicing of the EPO R gene, cDNA clones encoding a truncated form of the EPO R as well as a soluble form of EPO R has been found. The presence of a soluble form of the EPO R has also been detected in human sera. Recombinant soluble EPO R binds EPO with high affinity and is a potent EPO antagonist.
- Barber, D.L. and A.D. D’Andrea (1992) Seminars in Hematology 29:293.
- Youssoufian, H. et al. (1993) Blood 9:2223.
- Lodish, H.F. et al. (1995) Cold Spring Harbor Symposia on Quantitative Biology LX:93.
- Baynes, R.D. et al. (1993) Blood 82:2088.
Citations for Recombinant Human Erythropoietin R Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 5
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Second-generation non-hematopoietic erythropoietin-derived peptide for neuroprotection
Authors: B Cho, SJ Yoo, SY Kim, CH Lee, YI Lee, SR Lee, C Moon
Redox Biology, 2021;49(0):102223.
Sample Types: Protein
Applications: Surface Plasmon Resonance
The concentration of brain homogenates with the Amicon Ultra Centrifugal filters
Authors: J Yang, RK Sumbria
Sample Types: Tissue Homogenates
Applications: ELISA Capture
Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease.
Authors: Khankin EV, Mutter WP, Tamez H
PLoS ONE, 2010;5(2):e9246.
Sample Types: N/A
Applications: Specificity testing
Thrombopoietin contributes to enhanced platelet activation in cigarette smokers.
Authors: Lupia E, Bosco O, Goffi A
Sample Types: Plasma
Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.
Authors: DR Burrill, Burrill D, Vernet A, A Vernet, JJ Collins, PA Silver, JC Way, Way J
Proc Natl Acad Sci U S A, 0;113(19):5245-50.
Sample Types: Recombinant Protein
Applications: Enzyme Assay
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