alpha -Synuclein is member of a family of small soluble proteins that include also beta -, and gamma -Synuclein. It is predominantly expressed in neurons of the central nervous system in the presynaptic region of nerve terminals, where it cycles between a free, partially unfolded and a helical, membrane-bound form. alpha -Synuclein can self-aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates. The fibrils and amyloidal forms of alpha -Synuclein are major components of Lewy bodies and Lewy neurites and have been linked to the pathogenesis of Parkinson’s Disease, Parkinson’s Disease Dementia, and dementia with Lewy bodies. alpha -Synuclein aggregates can be also found associated with amyloid plaques in Alzheirmer’s Disease.
Recombinant Human His6-alpha-Synuclein Protein, CF
R&D Systems | Catalog # SP-480
Key Product Details
- R&D Systems E. coli-derived Recombinant Human His6-alpha-Synuclein Protein (SP-480)
- Quality control testing to verify active proteins with lot specific assays by in-house scientists
- All R&D Systems proteins are covered with a 100% guarantee
Source
Accession Number
Applications
Product Specifications
Source
Met1 - Ala140 with a C-terminal 6-His tag
Purity
Predicted Molecular Mass
Activity
Recombinant Human His6-alpha -Synuclein is ideal for use as a control substrate for in vitro Ubiquitin conjugation using select Ubiquitin E3 ligases such as CHIP/Stub1. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human His6-alpha -Synuclein concentration of 0.5-2.5 μM.
Formulation, Preparation, and Storage
SP-480
| Formulation | Supplied as a 0.2 μm filtered solution in HEPES and NaCl. |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: alpha-Synuclein
References
-
Breydo L, et al. (2012) Biochim. Biophys. Acta. 1822: 261.
-
Chen R.H., et al. (2013) J. Biol. Chem. 288: 7438.
-
Li X., et al. (2008) Acta Biochim. Biophys. Sin (Shanghai) 40: 406.
-
Surguchov A. (2008) Int. Rev. Cell Mol. Biol. 270: 225.
-
Xia Q., et al. (2008) Front. Biosci. 13: 3850.
Alternate Names
Gene Symbol
UniProt
Additional alpha-Synuclein Products
Product Documents for Recombinant Human His6-alpha-Synuclein Protein, CF
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Recombinant Human His6-alpha-Synuclein Protein, CF
For research use only
Related Research Areas
Citations for Recombinant Human His6-alpha-Synuclein Protein, CF
Powered by Bioz
Customer Reviews for Recombinant Human His6-alpha-Synuclein Protein, CF
There are currently no reviews for this product. Be the first to review Recombinant Human His6-alpha-Synuclein Protein, CF and earn rewards!
Have you used Recombinant Human His6-alpha-Synuclein Protein, CF?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review