Recombinant Human IL-11 R alpha Protein, CF

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Recombinant Human IL-11 R alpha Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its ability to bind recombinant human IL-11 in a functional ELISA with an estimated Kd <1 nM.
Chinese Hamster Ovary cell line, CHO-derived human IL-11 R alpha protein
Ser24-Val363, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Ser24 & Cys26
Predicted Molecular Mass
38 kDa
40-55 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: IL-11 R alpha

Interleukin-11 receptor alpha (IL-11 R alpha ) is a 49 kDa type I transmembrane member of the gp130 subfamily of the hematopoietic cytokine receptor family (1-3). Mature human IL-11 R alpha consists of a 347 amino acid (aa) extracellular domain (ECD) that contains a C2 type Ig-like domain, two fibronectin type III domains, two potential glycosylation sites, and a WSxWS motif, followed by a 21 aa transmembrane region and a 31 aa cytoplasmic domain (4). Within the ECD, human IL-11 R alpha shares 84%, 82%, 90%, and 86% aa sequence identity with mouse, rat, equine, and bovine IL-11 R alpha, respectively. Alternative splicing generates an additional isoform that lacks the cytoplasmic domain (4). Upon low affinity binding to IL-11, IL-11 R alpha associates with gp130 to form a high affinity receptor complex (1, 3). gp130 also functions as a subunit in the receptors for Cardiotrophin-1, CNTF, IL-6, IL-27, IL-31, LIF, and Oncostatin M (5). IL-11 R alpha is widely expressed in adults, embryos, and embryonic stem cells (4, 6, 7). Deletion of IL-11 R alpha in female mice causes faulty decidualization, lack of decidual NK cells, and infertility (8-10). IL-11 is anti-apoptotic for oligodendrocytes, and lack of IL-11 R alpha increases the severity of experimental autoimmune encephalitis (11, 12). IL-11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL-11 signaling may be a factor in inflammation-associated gastrointestinal cancer development (3, 13). IL-11 R alpha enhances osteoclast differentiation and bone remodeling but inhibits adipocyte differentiation (1, 2). Recombinant soluble IL-11 R alpha confers IL-11 responsiveness to cells expressing gp130, while in cells expressing transmembrane IL-11 R alpha and gp130, soluble IL-11 R alpha acts as an IL-11 antagonist (14-16).

  1. Sims, N.A. and N.C. Walsh (2010) BMB Reports 43:513.
  2. White, U.A. and J.M. Stephens (2011) Curr. Pharm. Des. 17:340.
  3. Kiessling, S. et al. (2004) J. Biol. Chem. 279:10304.
  4. Cherel, M. et al. (1995) Blood 86:2534.
  5. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.
  6. Hilton, D.J. et al. (1994) EMBO J. 13:4765.
  7. Davidson, A.J. et al. (1997) Stem Cells 15:119.
  8. Paiva, P. et al. (2009) Cytokine Growth Factor Rev. 20:319.
  9. Robb, L. et al. (1998) Nat. Med. 4:303.
  10. Ain, R. et al. (2004) Dev. Dyn. 231:700.
  11. Gurfein, B.T. et al. (2009) J. Immunol. 183:4229.
  12. Zhang, J. et al. (2011) J. Immunol. 187:1129.
  13. Putoczki, T. and M. Ernst (2010) J. Leukoc. Biol. 88:1109.
  14. Curtis, D.J. et al. (1997) Blood 90:4403.
  15. Baumann, H. et al. (1996) J. Immunol. 157:284.
  16. Karow, J. et al. (1996) Biochem. J. 318:489.
Long Name
Interleukin 11 Receptor alpha
Entrez Gene IDs
3590 (Human); 16157 (Mouse)
Alternate Names
AI314697; GP130; IL-11 R alpha; IL11R alpha; IL11RA; IL-11Ra; Il11ra2; NR1

Citations for Recombinant Human IL-11 R alpha Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells
    Authors: M Lindkvist, MM Zegeye, M Grenegård, LU Ljungberg
    International Journal of Molecular Sciences, 2022;23(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
    Authors: J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja
    Nature Communications, 2021;12(1):66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor
    Authors: P Aryappalli, K Shabbiri, RJ Masad, RH Al-Marri, SM Haneefa, YA Mohamed, K Arafat, S Attoub, O Cabral-Mar, KB Ramadi, MJ Fernandez-, BK Al-Ramadi
    Int J Mol Sci, 2019;20(18):.
    Species: Insect
    Sample Types: Honey
    Applications: Bioassay


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Recombinant Human IL-11 R alpha Protein, CF
By Anonymous on 05/26/2020
Application: Stability by SEC.
Reason for Rating: 92% monomer by SEC.