Recombinant Human IL-37/IL-1F7 Protein, CF

rh IL-37 Isoform b (7585-IL) is also available!
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Citations (7)
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Recombinant Human IL-37/IL-1F7 Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Human (rh) IL‑18 R alpha /IL‑1 R5 Fc Chimera (Catalog # 816-LR) is immobilized at 2 μg/mL (100 μL/well), the concentration of rhIL-37/IL-1F7 Chimera that produces 50% optimal binding response is 20-120 ng/mL.
E. coli-derived human IL-37/IL-1F7 protein
Lys27-Asp192, with an N-terminal Met
Accession #
N-terminal Sequence
Predicted Molecular Mass
18.6 kDa

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS and DTT.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: IL-37/IL-1F7

Human Interleukin-1 family member 7 (IL-1F7), also named FIL-1 zeta, IL‑37, IL‑1H4, IL-1HL and IL‑1RP1, is an anti-inflammatory member of the IL‑1 cytokine family (1-3). Alternative splicing generates multiple isoforms (IL‑37a through e) with deletions in the N-terminal region of the molecule (4-7). The longest IL-1F7 transcript encodes IL-37b, which shares approximately 21%, 24%, and 30% aa sequence identity with mature IL-1 alpha, IL‑1 beta, and IL-1ra, respectively. Mouse IL‑37 has not been reported, but human IL‑37b is active on mouse cells. Like IL‑1 alpha, IL‑1 beta and IL‑18, all of the IL‑37 variants lack a typical signal peptide. IL-37b is up-regulated by inflammatory stimuli in peripheral blood mononuclear cells (8). Experimental over-expression of IL‑37b in vivo limits the inflammatory response and protects mice from colitis and LPS-induced shock (8, 9). Both unprocessed and mature IL‑37b can form homodimers in solution (8, 10). Although IL‑37b will bind to IL‑18 R alpha with low affinity, this has no effect on IL‑18 receptor activity (7, 10, 11). Alternatively, IL‑37b will also bind to IL‑18 BP, generating a complex that interacts with IL‑18 R beta. This has the effect of attenuating IL‑18 activity via the IL‑18 receptor (11). IL‑37b can also function intracellularly. Following LPS‑induced cleavage of its propeptide, IL‑37b associates with Smad3 and translocates to the nucleus. This results in a reduction of pro‑inflammatory cytokine secretion (12).

  1. Dinarello, C.A. and P. Bufler (2013) Sem. Immunol. 25:466.
  2. Boraschi, D. et al. (2011) Eur. Cytokine Netw. 22:127.
  3. Ding, V.A. et al. (2016) Med. Oncol. 33:68.
  4. Smith, D.E. et al. (2000) J. Biol Chem 275:1169.
  5. Kumar S. et al. (2000) J. Biol Chem 275:10308.
  6. Busfield S.J. et al. (2000) Genomics 66:213.
  7. Pan, G. et al. (2000) Cytokine 13:1.
  8. Nold, M.F. et al. (2010) Nat. Immunol. 11:1014.
  9. McNamee, E.N. et al. (2011) Proc. Natl. Acad. Sci. USA 108:16711.
  10. Kumar S. et al. (2002) Cytokine 18:61.
  11. Bufler, P. et al. (2002) Proc. Natl. Acad. Sci. USA 99:13723.
  12. Sharma, S. et al. (2008) J. Immunol. 180:5477.
Long Name
Interleukin 37
Entrez Gene IDs
27178 (Human)
Alternate Names
FIL1 zeta; FIL1; FIL1(ZETA); FIL1ZFIL1 zeta; IL-1F7; IL-1F7IL-1 zeta; IL1H4IL1F7 (canonical product IL-1F7b); IL-1H4IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1RP1IL-1X protein; IL1RP1interleukin 1 family member 7; IL-1X; IL37; IL-37; interleukin 1 family, member 7 (zeta); interleukin 1, zeta; interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; Interleukin-1-related protein

Citations for Recombinant Human IL-37/IL-1F7 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis
    Authors: N Ma, C Yuan, J Shi, Q Zhu, Y Liu, X Ma, B Li, W Gong, J Xue, G Lu, W Li, J Li
    JCI Insight, 2022;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  2. Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP)
    Authors: Y Zhao, X Ni, P Xu, Q Liu, T Sun, X Liu, X Ji, J Qiu, J Li, S Wang, P Han, J Peng, M Hou, G Li
    Cytokine, 2019;125(0):154853.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway
    Authors: C Ye, W Zhang, K Hang, M Chen, W Hou, J Chen, X Chen, E Chen, L Tang, J Lu, Q Ding, G Jiang, B Hong, R He
    Cell Death Dis, 2019;10(10):753.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation
    Authors: L Li, J Wei, S Li, AM Jacko, NM Weathingto, RK Mallampall, J Zhao, Y Zhao
    EBioMedicine, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner
    Authors: M Zhao, Y Li, C Guo, L Wang, H Chu, F Zhu, Y Li, X Wang, Q Wang, W Zhao, Y Shi, W Chen, L Zhang
    Cell Death Dis, 2018;9(6):582.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Transfection
  6. IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway
    Authors: M Jiang, Y Wang, H Zhang, Y Ji, P Zhao, R Sun, C Zhang
    Thorac Cancer, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay


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