Recombinant Human IL-39 Fc Chimera Protein, CF Summary
Accession # Q14213
Accession # Q9NPF7
Recombinant Human IL-39 Fc Chimera (Catalog # 9990-IL) induces IFN-gamma production in mousesplenocytes. The ED50 for this effect is 50-250 ng/mL.
2 μg/lane of Recombinant Human IL-39 was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 70-77 kDa and 140-160 kDa, respectively.
Background: IL-39 (IL-23p19/EBI3)
Interleukin 39 (IL-39) is a member of the IL-12 family of heterodimeric cytokines. IL-12 cytokines are composed of an alpha and beta subunit which, for IL-39 are the IL-23 p19 subunit and the EBI3 subunit, respectively (1-3). The IL-23 p19 subunit of IL-39 is synthesized as a 189 amino acid (aa) precursor protein with a 19 aa signal sequence and a 170 aa mature region. The EBI3 subunit of IL-39 is synthesized as a 229 aa precursor protein that contains a 20 aa signal sequence and a 209 aa mature region. Human and mouse IL-39 share 73% and 62% sequence homology in their IL-23 p19 and EBI3 subunits, respectively. Heterodimer (IL-39) is secreted by LPS-stimulated B cells and GL7(+) activated B cells of lupus-like mice (1, 4). IL-39 signals through IL-23 R/gp130 receptors and mediates inflammatory responses through activation of STAT1 and STAT3 in lupus-like mice (1, 2). IL‐39 induces and/or expands neutrophils in lupus‐prone mice, and IL‐39‐induced neutrophils increase the secretion of B cell activation factor (BAFF) (3). Thus, IL-39 is an important pro-inflammatory cytokine and play important roles in the pathophysiology of autoimmune diseases, including Systemic Lupus Erythematosus (SLE) (2, 4).
- Wang, X. et al. (2016) Eur J Immunol 46:1343.
- Hasegawa, H. et al. (2016) Front Immunol 7:479.
- Wang, X. et al. (2016) Clin Exp Immunol 186:144.
- Wang, X. et al. (2018) Mol Med Rep 17:1660.
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