Recombinant Human IL-7 Protein

Formulations:
Catalog # Availability Size / Price Qty
207-IL-005
207-IL-025
207-IL-200
207-IL-010
207-IL-050
Product Details
Citations (125)
FAQs
Supplemental Products
Reviews (8)

Recombinant Human IL-7 Protein Summary

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. USA 83:5894. The ED50 for this effect is 0.1-0.5 ng/mL.
The specific activity of Recombinant Human IL-7 is approximately 4.4 x 105 IU/μg, which is calibrated against human IL-7 WHO International Standard (NIBSC code: 90/530).
Source
E. coli-derived human IL-7 protein
Asp26-His177, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
17 kDa

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

207-IL

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

207-IL/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution Reconstitute 5 μg vials at 50 μg/mL in sterile PBS. Reconstitute 25 μg or larger vials at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-7

IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1‑4). Human
IL‑7 cDNA encodes 177 amino acids (aa) that include a 25 aa signal peptide (3). Human IL-7 shares approximately 60-63% aa sequence identity with mouse, rat, canine and feline IL-7, and 72-76% with equine, bovine, ovine, porcine, feline and canine IL-7.  Human and mouse IL-7 exhibit cross-species activity (2, 3). IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). Circulating IL-7 is limiting in healthy animals, but increases during lymphopenia (1, 6). IL-7 signals through a complex of the IL-7 Receptor alpha subunit (IL-7 R alpha, also known as CD127) with the common gamma chain ( gamma c) (1). The gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21 (1). IL-7 R alpha is expressed on double negative (CD4-CD8-) and CD4+ or CD8+ single positive naïve and memory T cells, but undergoes IL-7-mediated down‑regulation and shedding during antigen-driven T cell proliferation, and is absent on regulatory T cells (1, 2, 6-11). IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). It is required for optimal T cell-dendritic cell interaction (6). IL-7 is expressed early in B cell development prior to the appearance of surface IgM (1, 5, 9). In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development (4, 9, 12, 13). However, IL-7 functions in both mouse and human pro-B cells to suppress premature Ig light chain recombination during proliferative growth (14, 15).

References
  1. Sasson, S.C. et al. (2006) Curr. Drug Targets 7:1571.
  2. Barata, J.T. et al. (2006) Exp. Hematol. 34:1133.
  3. Goodwin, R.G. et al. (1990) Proc. Natl. Acad. Sci. USA 86:302.
  4. Namen, A.E. et al. (1988) Nature 333:571.
  5. Shalapour, S. et al. (2012) PLoS ONE 7: e31939.
  6. Saini, M. et al. (2009) Blood 113:5793.
  7. Park, J.H. et al. (2004) Immunity 21:289.
  8. Vranjkovic, A. et al. (2007) Int. Immunol. 19:1329.
  9. Sudo, T. et al. (1993) Proc. Natl. Acad. Sci. 90:9125.
  10. Seddon, B. et al. (2003) Nat. Immunol. 4:680.
  11. Schluns, K.S. et al. (2000) Nat. Immunol. 5:426.
  12. Peschon, J.J. et al. (1994) J. Exp. Med. 180:1955.
  13. Pribyl, J.A. and T.W. LeBien (1996) Proc. Natl. Acad. Sci. 93:10348.
  14. Johnson, K. et al. (2012) J. Immunol. 188:6084.
  15. Nodland, S.E. et al. (2011) Blood 118:2116.
Long Name
Interleukin 7
Entrez Gene IDs
3574 (Human); 16196 (Mouse); 25647 (Rat)
Alternate Names
IL7; IL-7; IL-7interleukin-7; interleukin 7; Lymphopoietin-1; PBGF

Citations for Recombinant Human IL-7 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

125 Citations: Showing 1 - 10
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  1. Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines
    Authors: N Borthwick, S Silva-Arri, A Llano, M Takiguchi, C Brander, T Hanke
    Vaccines (Basel), 2020;8(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy
    Authors: NL Truex, RL Holden, BY Wang, PG Chen, S Hanna, Z Hu, K Shetty, O Olive, D Neuberg, N Hacohen, DB Keskin, PA Ott, CJ Wu, BL Pentelute
    Sci Rep, 2020;10(1):723.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
    Authors: SR Ferdosi, R Ewaisha, F Moghadam, S Krishna, JG Park, MR Ebrahimkha, S Kiani, KS Anderson
    Nat Commun, 2019;10(1):1842.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity
    Authors: C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen, P Hickey, VC Wimmer, L Whitehead, K Rogers, GK Smyth, AL Garnham, ME Ritchie, GT Belz
    Nat. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  5. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency
    Authors: DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, VR Tobin, D Goodman, E Shifrut, JA Bluestone, JM Puck, FC Szoka, A Marson
    Nat. Biotechnol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  6. Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II?induced arthritis
    Authors: ZY Li, JJ Zhou, CL Luo, LM Zhang
    Mol Med Rep, 2019;20(5):4540-4550.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection
    Authors: A Guvenel, A Jozwik, S Ascough, SK Ung, S Paterson, M Kalyan, Z Gardener, E Bergstrom, S Kar, MS Habibi, A Paras, J Zhu, M Park, J Dhariwal, M Almond, EH Wong, A Sykes, J Del Rosari, MB Trujillo-T, P Mallia, J Sidney, B Peters, OM Kon, A Sette, SL Johnston, PJ Openshaw, C Chiu
    J. Clin. Invest., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice
    Authors: JD Ventura, J Beloor, E Allen, T Zhang, KA Haugh, PD Uchil, C Ochsenbaue, C Kieffer, P Kumar, TJ Hope, W Mothes
    PLoS Pathog., 2019;15(12):e1008161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations
    Authors: C Ammer-Herr, U Kulkarni, N Andreas, M Ungelenk, S Ravens, C Hübner, A Kather, I Kurth, M Bauer, T Kamradt
    PLoS ONE, 2019;14(2):e0211716.
    Species: Mouse
    Sample Types: In Vivo
  10. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
    Authors: JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles
    Nat. Immunol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. In�Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells
    Authors: K Kuranda, S Caillat-Zu, S You, R Mallone
    Mol Ther Methods Clin Dev, 2019;13(0):112-120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
    Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
    Nat Commun, 2019;10(1):709.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function
    Authors: S Whelan, E Ophir, MF Kotturi, O Levy, S Ganguly, L Leung, I Vaknin, S Kumar, L Dassa, K Hansen, D Bernados, B Murter, A Soni, JM Taube, AN Fader, TL Wang, IM Shih, M White, DM Pardoll, SC Liang
    Cancer Immunol Res, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies
    Authors: HJ Yoo, Y Liu, L Wang, ML Schubert, JM Hoffmann, S Wang, B Neuber, A Hückelhove, U Gern, A Schmitt, C Müller-Tid, P Dreger, A Mokhir, M Schmitt, L Sellner
    Int J Mol Sci, 2019;20(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)
  15. Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
    Authors: X Zhao, S Sankaran, J Yap, CT Too, ZZ Ho, G Dolton, M Legut, EC Ren, AK Sewell, A Bertoletti, PA MacAry, J Brzostek, NRJ Gascoigne
    Nat Commun, 2018;9(1):2716.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration
    Authors: LK Thampy, KE Remy, AH Walton, Z Hong, K Liu, R Liu, V Yi, CD Burnham, RS Hotchkiss
    PLoS ONE, 2018;13(6):e0199497.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential
    Authors: DJHF Knapp, CA Hammond, T Hui, MTJ van Loenho, F Wang, N Aghaeepour, PH Miller, M Moksa, GM Rabu, PA Beer, D Pellacani, RK Humphries, C Hansen, M Hirst, CJ Eaves
    Nat. Cell Biol., 2018;20(6):710-720.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors
    Authors: Y Hijikata, T Okazaki, Y Tanaka, M Murahashi, Y Yamada, K Yamada, A Takahashi, H Inoue, J Kishimoto, Y Nakanishi, Y Oda, Y Nakamura, K Tani
    PLoS ONE, 2018;13(1):e0187878.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells
    Authors: U Kulkarni, C Herrmenau, SJ Win, M Bauer, T Kamradt
    PLoS ONE, 2018;13(2):e0192304.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  20. Human papilloma virus specific immunogenicity and dysfunction of CD8+ T cells in head and neck cancer
    Authors: S Krishna, P Ulrich, E Wilson, F Parikh, P Narang, S Yang, AK Read, S Kim-Schulz, JG Park, M Posner, MA Wilson Say, A Sikora, KS Anderson
    Cancer Res., 2018;0(0):.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  21. Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma
    Authors: S Nagel, C Pommerenke, C Meyer, M Kaufmann, RAF MacLeod, HG Drexler
    Oncotarget, 2018;9(18):14338-14353.
    Species: Human
    Sample Types: Whole Cells
  22. The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer
    Authors: S Miyamoto, V Kochin, T Kanaseki, A Hongo, S Tokita, Y Kikuchi, A Takaya, Y Hirohashi, T Tsukahara, T Terui, K Ishitani, F Hata, I Takemasa, A Miyazaki, H Hiratsuka, N Sato, T Torigoe
    Cancer Immunol Res, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells
    Authors: T Kato, T Matsuda, Y Ikeda, JH Park, M Leisegang, S Yoshimura, T Hikichi, M Harada, M Zewde, S Sato, K Hasegawa, K Kiyotani, Y Nakamura
    Oncotarget, 2018;9(13):11009-11019.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition
    Authors: SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi
    Oncotarget, 2018;9(49):29193-29207.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition
    Authors: M Bardet, A Unterreine, C Malinverni, F Lafossas, C Vedrine, D Boesch, Y Kolb, D Kaiser, A Glück, MA Schneider, A Katopodis, M Renatus, O Simic, A Schlapbach, J Quancard, CH Régnier, G Bold, C Pissot-Sol, JM Carballido, J Kovarik, T Calzascia, F Bornancin
    Immunol. Cell Biol., 2018;96(1):81-99.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells
    Authors: M Nakajima, M Kawaguchi, M Matsuyama, K Ota, J Fujita, S Matsukura, SK Huang, Y Morishima, Y Ishii, H Satoh, T Sakamoto, N Hizawa
    Int. Arch. Allergy Immunol., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool
    Authors: J Fu, J Zuber, M Martinez, B Shonts, A Obradovic, H Wang, SP Lau, A Xia, EE Waffarn, K Frangaj, TM Savage, MT Simpson, S Yang, XV Guo, M Miron, T Senda, K Rogers, A Rahman, SH Ho, Y Shen, A Griesemer, DL Farber, T Kato, M Sykes
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells
    Authors: C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom
    Hum Vaccin Immunother, 2018;0(0):0.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
    Authors: D Chennamadh, NA Saavedra-A, LJ Carreño, MJ Guberman-P, P Arora, T Yongqing, HF Koay, DI Godfrey, S Keshipeddy, SK Richardson, S Sundararaj, JH Lo, X Wen, JA Gascón, W Yuan, J Rossjohn, J Le Nours, SA Porcelli, AR Howell
    Cell Chem Biol, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. IL-7 unveils pathogen-specific T cells by enhancing antigen-recall responses
    Authors: N Terrazzini, P Mantegani, F Kern, C Fortis, A Mondino, S Caserta
    J. Infect. Dis., 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Cell Culture
  31. Molecular transitions in early progenitors during human cord blood hematopoiesis
    Authors: S Zheng, E Papalexi, A Butler, W Stephenson, R Satija
    Mol. Syst. Biol., 2018;14(3):e8041.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Detection and Characterization of CD8+ Autoreactive Memory Stem T Cells in Patients with Type 1 Diabetes
    Authors: D Vignali, E Cantarelli, C Bordignon, A Canu, A Citro, A Annoni, L Piemonti, P Monti
    Diabetes, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
    Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
    Clin. Cancer Res, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Interferon-?-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity
    Authors: T Koya, R Yanagisawa, Y Higuchi, K Sano, S Shimodaira
    Sci Rep, 2017;7(0):42145.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors
    Authors: C Gavegnano, JH Brehm, FP Dupuy, A Talla, SP Ribeiro, DA Kulpa, C Cameron, S Santos, SJ Hurwitz, VC Marconi, JP Routy, L Sabbagh, RF Schinazi, RP Sékaly
    PLoS Pathog., 2017;13(12):e1006740.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
    Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
    Am J Transl Res, 2017;9(2):454-465.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency
    Authors: M Yoshida, Y Ishioka, T Ozawa, H Okuyama, M Iguchi, T Ota, T Ito, M Nagira, A Morita, H Tanaka, H Naito, H Kidoya, N Takakura
    Sci Rep, 2017;7(1):11137.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes
    Authors: CA Ramos, B Ballard, H Zhang, O Dakhova, AP Gee, Z Mei, M Bilgi, MF Wu, H Liu, B Grilley, CM Bollard, BH Chang, CM Rooney, MK Brenner, HE Heslop, G Dotti, B Savoldo
    J. Clin. Invest., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Cellular Immune Responses to Live Attenuated Japanese Encephalitis (JE) Vaccine SA14-14-2 in Adults in a JE/Dengue Co-Endemic Area
    Authors: L Turtle, F Tatullo, T Bali, V Ravi, M Soni, S Chan, S Chib, MM Venkataswa, P Fadnis, M Ya‹ch, S Fernandez, P Klenerman, V Satchidana, T Solomon
    PLoS Negl Trop Dis, 2017;11(1):e0005263.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation
    Authors: F Venet, J Demaret, BJ Blaise, C Rouget, T Girardot, E Idealisoa, T Rimmelé, F Mallet, A Lepape, J Textoris, G Monneret
    J. Immunol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017;14(5):531-538.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps
    Authors: JA Poposki, AI Klingler, BK Tan, P Soroosh, H Banie, G Lewis, KE Hulse, WW Stevens, AT Peters, LC Grammer, RP Schleimer, KC Welch, SS Smith, DB Conley, JR Raviv, JG Karras, O Akbari, RC Kern, A Kato
    Immun Inflamm Dis, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia
    Authors: J Ding, ML Fishel, AM Reed, E McAdams, M Czader, AA Cardoso, MR Kelley
    Mol. Cancer Ther., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells
    Authors: A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May
    Blood Adv, 2017;1(10):577-589.
    Species: Human
    Sample Types: Whole Cells
  45. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
    Authors: Y Van Caeneg, S De Munter, P Tieppo, G Goetgeluk, K Weening, G Verstichel, S Bonte, T Taghon, G Leclercq, T Kerre, R Debets, D Vermijlen, H Abken, B Vandekerck
    Oncoimmunology, 2017;6(3):e1283460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes
    Authors: RB Jones, S Mueller, R O'Connor, K Rimpel, DD Sloan, D Karel, HC Wong, EK Jeng, AS Thomas, JB Whitney, SY Lim, C Kovacs, E Benko, S Karandish, SH Huang, MJ Buzon, M Lichterfel, A Irrinki, JP Murry, A Tsai, H Yu, R Geleziunas, A Trocha, MA Ostrowski, Irvi
    PLoS Pathog, 2016;12(4):e1005545.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5
    PLoS Pathog., 2016;12(11):e1006007.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects
    Stem Cell Reports, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Interleukin-7 Plasma Levels in Human Differentiate Anorexia Nervosa, Constitutional Thinness and Healthy Obesity
    PLoS ONE, 2016;11(9):e0161890.
    Species: Human
    Sample Types: Protein
    Applications: ELISA (Standard)
  50. P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART
    Authors: I Menkova-Ga, H Hocini, E Foucat, P Tisserand, L Bourdery, C Delaugerre, C Benne, Y Lévy, JD Lelièvre
    PLoS Pathog, 2016;12(4):e1005571.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance
    Oncoimmunology, 2016;5(6):e1165376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
    Authors: Vesna Pulko
    Nat Immunol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo
    Stem Cells, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Human MAIT-cell responses to Escherichia coli: activation, cytokine production, proliferation, and cytotoxicity
    Authors: J Dias, MJ Sobkowiak, JK Sandberg, E Leeansyah
    J Leukoc Biol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis
    Authors: Anja Kerstein
    J. Autoimmun, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia
    Mol Ther, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)
  57. Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.
    Authors: Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Narita M, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M
    Leukemia, 2015;29(12):2393-401.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Cooperation between IL-7 Receptor and Integrin alpha2beta1 (CD49b) Drives Th17-Mediated Bone Loss.
    Authors: El Azreq M, Arseneault C, Boisvert M, Page N, Allaeys I, Poubelle P, Tessier P, Aoudjit F
    J Immunol, 2015;195(9):4198-209.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma.
    Authors: Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K
    PLoS ONE, 2015;10(11):e0130464.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.
    Authors: Huang X, Park H, Greene J, Pao J, Mulvey E, Zhou S, Albert C, Moy F, Sachdev D, Yee D, Rader C, Hamby C, Loeb D, Cairo M, Zhou X
    PLoS ONE, 2015;10(7):e0133152.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Hair regrowth in alopecia areata patients following Stem Cell Educator therapy.
    Authors: Li Y, Yan B, Wang H, Li H, Li Q, Zhao D, Chen Y, Zhang Y, Li W, Zhang J, Wang S, Shen J, Li Y, Guindi E, Zhao Y
    BMC Med, 2015;13(0):87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
    Authors: Leeansyah E, Svard J, Dias J, Buggert M, Nystrom J, Quigley M, Moll M, Sonnerborg A, Nowak P, Sandberg J
    PLoS Pathog, 2015;11(8):e1005072.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells.
    Authors: Artyomov M, Munk A, Gorvel L, Korenfeld D, Cella M, Tung T, Klechevsky E
    J Exp Med, 2015;212(5):743-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.
    Authors: Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase M, Herr W, Lemmermann N
    PLoS Pathog, 2015;11(7):e1005049.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Survivin-specific T cell receptor targets tumor but not T cells.
    Authors: Arber C, Feng X, Abhyankar H, Romero E, Wu M, Heslop H, Barth P, Dotti G, Savoldo B
    J Clin Invest, 2015;125(1):157-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube.
    Authors: Wyndham-Thomas C, Dirix V, Schepers K, Martin C, Hildebrand M, Goffard J, Domont F, Libin M, Loyens M, Locht C, Van Vooren J, Mascart F
    BMC Infect Dis, 2015;15(0):59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
    Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
    Mol Ther, 2015;23(2):387-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies.
    Authors: Li Z, Younger K, Gartenhaus R, Joseph A, Hu F, Baer M, Brown P, Davila E
    J Clin Invest, 2015;125(3):1081-97.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
    Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
    J Transl Med, 2015;13(0):197.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
    Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
    J Immunol, 2014;193(5):2297-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
    Authors: Banu, Nasirah, Chia, Adeline, Ho, Zi Zong, Garcia, Alfonso, Paravasivam, Komathi, Grotenbreg, Gijsbert, Bertoletti, Antonio, Gehring, Adam J
    Sci Rep, 2014;4(0):4166.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3- cells versus regulatory T cells: a whole blood perspective.
    Authors: Dupont G, Demaret J, Venet F, Malergue F, Malcus C, Poitevin-Later F, Morel J, Monneret G
    Cytokine, 2014;69(1):146-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.
    Authors: Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C
    Blood, 2014;123(20):3116-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas.
    Authors: Picco G, Beatson R, Taylor-Papadimitriou J, Burchell J
    Eur J Immunol, 2014;44(7):1947-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses.
    Authors: Gervassi, Ana, Lejarcegui, Nicholas, Dross, Sandra, Jacobson, Amanda, Itaya, Grace, Kidzeru, Elvis, Gantt, Soren, Jaspan, Heather, Horton, Helen
    PLoS ONE, 2014;9(9):e107816.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. IFN-alpha exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.
    Authors: Cha L, de Jong E, French M, Fernandez S
    J Immunol, 2014;193(5):2178-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans.
    Authors: Harris K, Ramachandran G, Basu S, Rollins S, Mann D, Cross A
    Eur J Immunol, 2014;44(3):752-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.
    Authors: Duluc D, Joo H, Ni L, Yin W, Upchurch K, Li D, Xue Y, Klucar P, Zurawski S, Zurawski G, Oh S
    J Immunol, 2014;192(12):5776-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells.
    Authors: Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J
    Aging Cell, 2014;13(4):744-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Engineering the human thymic microenvironment to support thymopoiesis in vivo.
    Authors: Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang O, Crooks G
    Stem Cells, 2014;32(9):2386-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes.
    Authors: Demotte N, Bigirimana R, Wieers G, Stroobant V, Squifflet J, Carrasco J, Thielemans K, Baurain J, Van Der Smissen P, Courtoy P, van der Bruggen P
    Clin Cancer Res, 2014;20(7):1823-33.
  82. A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.
    Authors: Lepore M, de Lalla C, Gundimeda S, Gsellinger H, Consonni M, Garavaglia C, Sansano S, Piccolo F, Scelfo A, Haussinger D, Montagna D, Locatelli F, Bonini C, Bondanza A, Forcina A, Li Z, Ni G, Ciceri F, Jeno P, Xia C, Mori L, Dellabona P, Casorati G, De Libero G
    J Exp Med, 2014;211(7):1363-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
    Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
    PLoS ONE, 2014;9(9):e106673.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins.
    Authors: Yang C, French A, Goh P, Pagnamenta A, Mettananda S, Taylor J, Knight S, Nathwani A, Roberts D, Watt S, Carpenter L
    Br J Haematol, 2014;166(3):435-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals.
    Authors: Bastidas S, Graw F, Smith M, Kuster H, Gunthard H, Oxenius A
    J Immunol, 2014;192(4):1732-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
    Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
    J Allergy Clin Immunol, 2014;134(2):373-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Activation of the leukemia plasmacytoid dendritic cell line PMDC05 by Toho-1, a novel IDO inhibitor.
    Authors: Yamahira A, Narita M, Iwabuchi M, Uchiyama T, Iwaya S, Ohiwa R, Nishizawa Y, Suzuki T, Yokoyama Y, Hashimoto S, Takizawa J, Sone H, Takahashi M
    Anticancer Res, 2014;34(8):4021-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
    Authors: Reynolds, C, Roderick, J E, LaBelle, J L, Bird, G, Mathieu, R, Bodaar, K, Colon, D, Pyati, U, Stevenson, K E, Qi, J, Harris, M, Silverman, L B, Sallan, S E, Bradner, J E, Neuberg, D S, Look, A T, Walensky, L D, Kelliher, M A, Gutierrez, A
    Leukemia, 2014;28(9):1819-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Wilms' Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses.
    Authors: Uttenthal B, Martinez-Davila I, Ivey A, Craddock C, Chen F, Virchis A, Kottaridis P, Grimwade D, Khwaja A, Stauss H, Morris E
    Br J Haematol, 2014;164(3):366-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes.
    Authors: Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A
    Eur J Immunol, 2013;43(3):793-804.
  91. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
    Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
    Clin Cancer Res, 2013;19(7):1858-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Measles virus causes immunogenic cell death in human melanoma.
    Authors: Donnelly, O G, Errington-Mais, F, Steele, L, Hadac, E, Jennings, V, Scott, K, Peach, H, Phillips, R M, Bond, J, Pandha, H, Harrington, K, Vile, R, Russell, S, Selby, P, Melcher, A A
    Gene Ther, 2013;20(1):7-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.
    Authors: Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old L, Gnjatic S, Shiku H
    Eur J Immunol, 2013;43(4):989-1000.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.
    Authors: Alonzo, Francis, Kozhaya, Lina, Rawlings, Stephen, Reyes-Robles, Tamara, DuMont, Ashley L, Myszka, David G, Landau, Nathanie, Unutmaz, Derya, Torres, Victor J
    Nature, 2013;493(7430):51-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  95. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
    Authors: Tang, Xin-Zi, Jo, Juandy, Tan, Anthony, Sandalova, Elena, Chia, Adeline, Tan, Kai Chah, Lee, Kang Hoe, Gehring, Adam J, De Libero, Gennaro, Bertoletti, Antonio
    J Immunol, 2013;190(7):3142-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.
    Authors: Chen Z, Kim S, Chamberlain N, Pickens S, Volin M, Volkov S, Arami S, Christman J, Prabhakar B, Swedler W, Mehta A, Sweiss N, Shahrara S
    J Immunol, 2013;190(10):5256-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes.
    Authors: Carlson L, De Geer A, Sveinbjornsson B, Orrego A, Martinsson T, Kogner P, Levitskaya J
    Oncoimmunology, 2013;2(3):e23618.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Functional OCT4-specific CD4 and CD8 T cells in healthy controls and ovarian cancer patients.
    Authors: Di J, Massuger L, Duiveman-de Boer T, Zusterzeel P, Figdor C, Torensma R
    Oncoimmunology, 2013;2(5):e24271.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. IL-7 Restores Lymphocyte Functions in Septic Patients.
    Authors: Venet F, Foray A, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, Monneret G
    J Immunol, 2012;189(10):5073-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.
    Authors: Brusic, Ana, Hainz, Ursula, Wadleigh, Martha, Neuberg, Donna, Su, Mei, Canning, Christin, Deangelo, Daniel J, Stone, Richard, Lee, Jeng-Shi, Mulligan, Richard, Ritz, Jerome, Dranoff, Glenn, Sasada, Tetsuro, Wu, Catherin
    Oncoimmunology, 2012;1(7):1095-1103.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
    Authors: Nielsen N, Odum N, Urso B, Lanier LL, Spee P
    PLoS ONE, 2012;7(2):e31959.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
    Authors: Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA
    J. Immunol., 2012;188(8):3745-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells.
    Authors: Ichii, Michiko, Frank, Mark Bar, Iozzo, Renato V, Kincade, Paul W
    Blood, 2012;119(7):1683-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001.
    Authors: Inderberg-Suso E, Trachsel S, Lislerud K, Rasmussen A, Gaudernack G
    Oncoimmunology, 2012;1(5):670-686.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
    Authors: Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O
    Blood, 2011;118(11):2993-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Barley as a green factory for the production of functional Flt3 ligand.
    Authors: Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdottir SM, Jonsson A, Balmer Y, Mantyla E, Orvar BL
    Biotechnol J, 2010;5(2):163-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.
    Authors: Unsinger J, McGlynn M, Kasten KR, Hoekzema AS, Watanabe E, Muenzer JT, McDonough JS, Tschoep J, Ferguson TA, McDunn JE, Morre M, Hildeman DA, Caldwell CC, Hotchkiss RS
    J. Immunol., 2010;184(7):3768-79.
  108. CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.
    Authors: Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM
    J. Immunol., 2010;185(11):6646-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
    Authors: Yammani RR, Long D, Loeser RF
    Arthritis Rheum., 2009;60(3):792-800.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma.
    Authors: Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D
    Int. J. Cancer, 2009;125(5):1092-101.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells.
    Authors: Lotem M, Machlenkin A, Hamburger T, Nissan A, Kadouri L, Frankenburg S, Gimmon Z, Elias O, David IB, Kuznetz A, Shiloni E, Peretz T
    Clin. Cancer Res., 2009;15(15):4968-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008;24(3):453-62.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  113. alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function.
    Authors: Gendron S, Boisvert M, Chetoui N, Aoudjit F
    Immunology, 2008;125(0):359.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
    Authors: Spiegl N, Didichenko S, McCaffery P, Langen H, Dahinden CA
    Blood, 2008;112(9):3762-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15.
    Authors: McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS
    Exp. Hematol., 2008;36(5):598-608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Ultrasensitive flow-based immunoassays using single-molecule counting.
    Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
    Clin. Chem., 2007;53(11):1990-5.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  117. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007;109(10):4272-9.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  118. BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3.
    Authors: Kersten C, Dosen G, Myklebust JH, Sivertsen EA, Hystad ME, Smeland EB, Rian E
    Exp. Hematol., 2006;34(1):72-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism.
    Authors: Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D
    J. Immunol., 2005;174(4):2376-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Human immunodeficiency virus type 2 DNA vaccine provides partial protection from acute baboon infection.
    Authors: Locher CP, Witt SA, Ashlock BM, Polacino P, Hu SL, Shiboski S, Schmidt AM, Agy MB, Anderson DM, Staprans SI, zur Megede J, Levy JA
    Vaccine, 2004;22(17):2261-72.
    Species: Primate - Papio cynocephalus (Yellow Baboon)
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.
    Authors: Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P
    J. Virol., 2002;76(22):11605-11.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
    Authors: O&amp;amp;apos;Connor DH
    J. Virol., 2002;76(22):11623-36.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  124. CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma.
    Authors: Heczey A, Louis C, Savoldo B, Dakhova O, Durett A, Grilley B, Liu H, Wu M, Mei Z, Gee A, Mehta B, Zhang H, Mahmood N, Tashiro H, Heslop H, Dotti G, Rooney C, Brenner M
    Mol Ther, 0;25(9):2214-2224.
    Species: Human
    Sample Types: Whole Cells
    Applications: CAR-T (Bioassay)
  125. Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.
    Authors: Du M, Guo P, Piao H, Wang S, Sun C, Jin L, Tao Y, Li Y, Zhang D, Zhu R, Fu Q, Li D
    J Immunol, 0;192(4):1502-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human IL-7 Protein
By Anonymous on 06/20/2020
Application: CellProlif

Recombinant Human IL-7 Protein
By Anonymous on 01/10/2020
Application: In vitro bioactivity in cell culture

Recombinant Human IL-7 Protein
By Anonymous on 02/07/2019
Application: CellProlif

Recombinant Human IL-7 Protein
By Anonymous on 06/14/2018
Application: Binding assay/Protein-protein interaction

Recombinant Human IL-7 Protein
By Anonymous on 06/14/2018
Application: Binding assay/Protein-protein interaction

Recombinant Human IL-7 Protein
By Anonymous on 04/09/2018
Application: Binding assay/Protein-protein interaction

Recombinant Human IL-7 Protein
By Anonymous on 11/17/2017
Application: Immunoassay Standard

The protein was used as a calibrator in an ELISA. MAB207 and AF207 were used as the matched pair antibodies in the ELISA.


Recombinant Human IL-7 Protein
By Anonymous on 11/03/2017
Application: Stem/Immune cell maintenance or differentiation