Recombinant Human Latrophilin 3 Protein Fc Chimera, CF

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R&D Systems Recombinant Proteins and Enzymes
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Recombinant Human Latrophilin 3 Protein Fc Chimera, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Human Latrophilin 3/LPHN3 Fc Chimera is immobilized at 0.5 µg/mL (100 µL/well), the concentration of Recombinant Human FLRT3 (Catalog # 2795-FL) that produces 50% of the optimal binding response is approximately 0.07-0.35 μg/mL
Chinese Hamster Ovary cell line, CHO-derived human Latrophilin 3/LPHN3 protein
Human Latrophilin 3
Accession # NP_056051
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
120 kDa

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: Latrophilin 3/LPHN3

Latrophilin-3 (LPHN3) is a 7-transmembrane protein in the family of adhesion GPCRs with large N-terminal extracellular regions (1, 2). The 847 amino acid (aa)
N-terminal region of human Latrophilin-3 contains a SUEL-like lectin domain, an Olfactomedin-like domain, an O-glycosylated mucin-like region, a hormone receptor domain, and a GPCR proteolysis site (GPS). Within this approximately 120 kDa region, human Latrophilin-3 shares 96% aa sequence identity with mouse and rat Latrophilin-3. Alternative splicing of human Latrophilin-3 generates additional isoforms with a 13 aa insertion or premature truncation in the N-terminal ECD (3). Latrophilin-3 is expressed in the brain cortex (3). It binds to FLRT1, 2, and 3 and Tenurin 1 (4, 5). Its binding in trans to post-synaptic FLRT3 at glutamatergic synapses supports the maintenance of excitatory synapses as well as the amplitude of glutamatergic transmission (4, 5). Polymorphisms of Latrophilin-3 are associated with susceptibility to attention deficit/hyperactivity disorder (ADHD) (3, 6). Latrophilin-3 is also expressed in fetal adrenal glands and is down-regulated in the adult (7).

  1. Promel, S. et al. (2012) Cell Rep. 2:321.
  2. Matsushita, H. et al. (1999) FEBS Lett. 443:348.
  3. Arcos-Burgos, M. et al. (2010) Mol. Pschiatry 15:1053.
  4. O’Sullivan, M.L. et al. (2012) Neuron 73:903.
  5. O’Sullivan, M.L. et al. (2014) Neural Dev. 9:7.
  6. Franke, B. et al. (2012) Mol. Psychiatry 17:960.
  7. Xing, Y. et al. (2009) Mol. Cell. Endocrinol. 300:43.
Entrez Gene IDs
23284 (Human); 319387 (Mouse); 170641 (Rat)
Alternate Names
CIRL3; Latrophilin 3; latrophilin homolog 3 (cow); LEC3; Lectomedin-3; LPHN3


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